Lymphocyte activation: A rapid test to predict allograft rejection

Evan M. Hersh; William T. Butler; Roger D. Rossen; Robert O. Morgen

doi:10.1038/226757a0

Lymphocyte activation: A rapid test to predict allograft rejection

Evan M. Hersh, William T. Butler, Roger D. Rossen, Robert O. Morgen

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

THE early detection of allograft rejection, before organ function deteriorates, is an important objective of clinical research in transplantation immunology. Because lymphocytes play a central part in graft rejection ^1,2, attention was focused on these cells in the circulation of graft recipients. We observed that the numbers of circulating lymphocytes that incorporate³H-thymidine rise significantly during organ allograft rejection and may predict rejection crises by 24-48 h.

Original language	English (US)
Pages (from-to)	757-758
Number of pages	2
Journal	Nature
Volume	226
Issue number	5247
DOIs	https://doi.org/10.1038/226757a0
State	Published - 1970
Externally published	Yes

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title = "Lymphocyte activation: A rapid test to predict allograft rejection",

abstract = "THE early detection of allograft rejection, before organ function deteriorates, is an important objective of clinical research in transplantation immunology. Because lymphocytes play a central part in graft rejection 1,2, attention was focused on these cells in the circulation of graft recipients. We observed that the numbers of circulating lymphocytes that incorporate3H-thymidine rise significantly during organ allograft rejection and may predict rejection crises by 24-48 h.",

author = "Hersh, {Evan M.} and Butler, {William T.} and Rossen, {Roger D.} and Morgen, {Robert O.}",

year = "1970",

doi = "10.1038/226757a0",

language = "English (US)",

volume = "226",

pages = "757--758",

journal = "Nature",

issn = "0028-0836",

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number = "5247",

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TY - JOUR

T1 - Lymphocyte activation

T2 - A rapid test to predict allograft rejection

AU - Hersh, Evan M.

AU - Butler, William T.

AU - Rossen, Roger D.

AU - Morgen, Robert O.

PY - 1970

Y1 - 1970

N2 - THE early detection of allograft rejection, before organ function deteriorates, is an important objective of clinical research in transplantation immunology. Because lymphocytes play a central part in graft rejection 1,2, attention was focused on these cells in the circulation of graft recipients. We observed that the numbers of circulating lymphocytes that incorporate3H-thymidine rise significantly during organ allograft rejection and may predict rejection crises by 24-48 h.

AB - THE early detection of allograft rejection, before organ function deteriorates, is an important objective of clinical research in transplantation immunology. Because lymphocytes play a central part in graft rejection 1,2, attention was focused on these cells in the circulation of graft recipients. We observed that the numbers of circulating lymphocytes that incorporate3H-thymidine rise significantly during organ allograft rejection and may predict rejection crises by 24-48 h.

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ER -

Lymphocyte activation: A rapid test to predict allograft rejection

Abstract

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