@article{9f7816cb8b204ccd9d05de39ca85b986,
title = "Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity",
abstract = "Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.",
author = "Harvey, \{Natasha L.\} and Srinivasan, \{R. Sathish\} and Dillard, \{Miriam E.\} and Johnson, \{Nicole C.\} and Witte, \{Marlys H.\} and Kelli Boyd and Sleeman, \{Mark W.\} and Guillermo Oliver",
note = "Funding Information: We thank N. Gale for the LYVE-1 antibody and for discussions; M. Kahn for advice regarding the BODIPY FL C16 assay; M. Yanagisawa for the Tie2-Cre mice; R. Jandacek and P. Tso for the fatty acid absorption assay; M. Self for technical assistance; Y. Lee, A. Lavado and T. Nastasi for help with tissue dissections; M. Straign for the blood chemistry analysis; L. Mann and G. Murti for electron microscopy; G. Neale for help with microarray analysis; A. McArthur for editing the manuscript; B. Sosa-Pineda for discussions and critical reading of the manuscript; and D. Wasserman and G. Grosveld for discussions. This work was supported in part by a grant from the US National Institutes of Health to G.O., a Cancer Center Support Grant and the American Lebanese Syrian Associated Charities.",
year = "2005",
month = oct,
doi = "10.1038/ng1642",
language = "English (US)",
volume = "37",
pages = "1072--1081",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "10",
}