Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis

Marlys H. Witte, Sarah K. Daley

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Although described since ancient times, the lymphatic system was not fully recognized as an integrated vasculature, circulation, and center of the immune network until the discipline of lymphology was established a little more than half a century ago. This chapter reviews its distinctive macroscopic and microscopic anatomy and the physiologic principles governing lymph formation, absorption, and propulsion. In addition, we discuss the pathobiology and therapeutic implications underlying common lymphatic disorders. Finally, links to cancer, its complications, and spread are highlighted.

Original languageEnglish (US)
Title of host publicationCancer Metastasis Through the Lymphovascular System
PublisherSpringer International Publishing
Pages187-198
Number of pages12
ISBN (Electronic)9783030930844
ISBN (Print)9783030930837
DOIs
StatePublished - Jan 1 2022

Keywords

  • Cancer
  • Lymphatic anatomy
  • Lymphatic pathophysiology
  • Lymphatic physiology
  • Lymphatic systemomics
  • Lymphogenous metastasis
  • Molecular lymphology

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology

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