Lymphangiogenesis and hemangiogenesis: Potential targets for therapy

Marlys H. Witte; Michael T. Dellinger; Donald M. McDonald; S. David Nathanson; Francesco M. Boccardo; Corradino C.C. Campisi; Jonathan P. Sleeman; Jeffrey E. Gershenwald

doi:10.1002/jso.21714

Lymphangiogenesis and hemangiogenesis: Potential targets for therapy

Marlys H. Witte, Michael T. Dellinger, Donald M. McDonald, S. David Nathanson, Francesco M. Boccardo, Corradino C.C. Campisi, Jonathan P. Sleeman, Jeffrey E. Gershenwald

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

This review updates historical background from century-old observations on embryonic lymphatic system development through current understanding of the molecular basis of lymphvasculogenesis/lymphangiogenesis ("molecular lymphology"), highlighting similarities and differences with analogous blood vasculature processes. Topics covered include molecular mechanisms in lymphatic development, structural adaptations of the lymphatic vasculature to particulate and cellular transport and trafficking, lymphogenous route of clinical cancer spread, preservation of delineated lymphatic pathways during cancer operations, and anti-lymphangiogenesis in cancer therapy.

Original language	English (US)
Pages (from-to)	489-500
Number of pages	12
Journal	Journal of Surgical Oncology
Volume	103
Issue number	6
DOIs	https://doi.org/10.1002/jso.21714
State	Published - May 1 2011

Keywords

angiogenesis
anti-lymphangiogenesis
lymphatic development
lymphogenous cancer spread

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.21714

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title = "Lymphangiogenesis and hemangiogenesis: Potential targets for therapy",

abstract = "This review updates historical background from century-old observations on embryonic lymphatic system development through current understanding of the molecular basis of lymphvasculogenesis/lymphangiogenesis ({"}molecular lymphology{"}), highlighting similarities and differences with analogous blood vasculature processes. Topics covered include molecular mechanisms in lymphatic development, structural adaptations of the lymphatic vasculature to particulate and cellular transport and trafficking, lymphogenous route of clinical cancer spread, preservation of delineated lymphatic pathways during cancer operations, and anti-lymphangiogenesis in cancer therapy.",

keywords = "angiogenesis, anti-lymphangiogenesis, lymphatic development, lymphogenous cancer spread",

author = "Witte, {Marlys H.} and Dellinger, {Michael T.} and McDonald, {Donald M.} and Nathanson, {S. David} and Boccardo, {Francesco M.} and Campisi, {Corradino C.C.} and Sleeman, {Jonathan P.} and Gershenwald, {Jeffrey E.}",

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T1 - Lymphangiogenesis and hemangiogenesis

T2 - Potential targets for therapy

AU - Witte, Marlys H.

AU - Dellinger, Michael T.

AU - McDonald, Donald M.

AU - Nathanson, S. David

AU - Boccardo, Francesco M.

AU - Campisi, Corradino C.C.

AU - Sleeman, Jonathan P.

AU - Gershenwald, Jeffrey E.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - This review updates historical background from century-old observations on embryonic lymphatic system development through current understanding of the molecular basis of lymphvasculogenesis/lymphangiogenesis ("molecular lymphology"), highlighting similarities and differences with analogous blood vasculature processes. Topics covered include molecular mechanisms in lymphatic development, structural adaptations of the lymphatic vasculature to particulate and cellular transport and trafficking, lymphogenous route of clinical cancer spread, preservation of delineated lymphatic pathways during cancer operations, and anti-lymphangiogenesis in cancer therapy.

AB - This review updates historical background from century-old observations on embryonic lymphatic system development through current understanding of the molecular basis of lymphvasculogenesis/lymphangiogenesis ("molecular lymphology"), highlighting similarities and differences with analogous blood vasculature processes. Topics covered include molecular mechanisms in lymphatic development, structural adaptations of the lymphatic vasculature to particulate and cellular transport and trafficking, lymphogenous route of clinical cancer spread, preservation of delineated lymphatic pathways during cancer operations, and anti-lymphangiogenesis in cancer therapy.

KW - angiogenesis

KW - anti-lymphangiogenesis

KW - lymphatic development

KW - lymphogenous cancer spread

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M3 - Review article

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EP - 500

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

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Lymphangiogenesis and hemangiogenesis: Potential targets for therapy

Abstract

Keywords

ASJC Scopus subject areas

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