Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity

Sang Kyou Lee, Bing Su, Stephen E. Maher, Alfred L.M. Bothwell

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


To characterize the function of the Ly-6A antigen in T cell activation, antisense Ly-6 RNA was expressed in a stably transfected antigen-specific T cell clone. Reduced Ly-6A expression results in inhibition of responses to antigen, anti-TCR (anti-T cell receptor) crosslinking and concanavalin A plus recombinant interleukin 1 and causes impairment of in vitro fyn tyrosine kinase activity. More substantial reduction of Ly-6A results in reduction of TCR expression. Analysis of mRNA species indicates that the reduction is specific for the TCR β chain. These data demonstrate that Ly-6A may regulate TCR expression and may be involved in early events of T cell activation via regulation of fyn tyrosine kinase activity.

Original languageEnglish (US)
Pages (from-to)2167-2176
Number of pages10
JournalEMBO Journal
Issue number9
StatePublished - 1994
Externally publishedYes


  • Antisense transfectants
  • Ly-6A
  • T cell activation
  • T cell receptor
  • fyn tyrosine kinase

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


Dive into the research topics of 'Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity'. Together they form a unique fingerprint.

Cite this