Lung Diseases of the Elderly: Cellular Mechanisms

Kori Ascher; Sharon J. Elliot; Gustavo A. Rubio; Marilyn K. Glassberg

doi:10.1016/j.cger.2017.07.001

Lung Diseases of the Elderly: Cellular Mechanisms

Kori Ascher, Sharon J. Elliot, Gustavo A. Rubio, Marilyn K. Glassberg

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

Original language	English (US)
Pages (from-to)	473-490
Number of pages	18
Journal	Clinics in Geriatric Medicine
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.cger.2017.07.001
State	Published - Nov 2017
Externally published	Yes

Keywords

Aging
COPD
Cellular senescence
Idiopathic pulmonary fibrosis
Stem cells

ASJC Scopus subject areas

Geriatrics and Gerontology

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10.1016/j.cger.2017.07.001

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title = "Lung Diseases of the Elderly: Cellular Mechanisms",

abstract = "Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.",

keywords = "Aging, COPD, Cellular senescence, Idiopathic pulmonary fibrosis, Stem cells",

author = "Kori Ascher and Elliot, {Sharon J.} and Rubio, {Gustavo A.} and Glassberg, {Marilyn K.}",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = nov,

doi = "10.1016/j.cger.2017.07.001",

language = "English (US)",

volume = "33",

pages = "473--490",

journal = "Clinics in Geriatric Medicine",

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T1 - Lung Diseases of the Elderly

T2 - Cellular Mechanisms

AU - Ascher, Kori

AU - Elliot, Sharon J.

AU - Rubio, Gustavo A.

AU - Glassberg, Marilyn K.

PY - 2017/11

Y1 - 2017/11

N2 - Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

AB - Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

KW - Aging

KW - COPD

KW - Cellular senescence

KW - Idiopathic pulmonary fibrosis

KW - Stem cells

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DO - 10.1016/j.cger.2017.07.001

M3 - Review article

C2 - 28991645

AN - SCOPUS:85027568201

SN - 0749-0690

VL - 33

SP - 473

EP - 490

JO - Clinics in Geriatric Medicine

JF - Clinics in Geriatric Medicine

IS - 4

ER -

Lung Diseases of the Elderly: Cellular Mechanisms

Abstract

Keywords

ASJC Scopus subject areas

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