Lung Diseases of the Elderly: Cellular Mechanisms

Kori Ascher, Sharon J. Elliot, Gustavo A. Rubio, Marilyn K. Glassberg

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, apoptosis, and stem cell exhaustion. Aging, combined with the loss of protective repair processes, correlates with the development and incidence of chronic respiratory diseases, including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Ultimately, it is the interplay of age-related changes in biology and the subsequent responses to environmental exposures that largely define the physiology and clinical course of the aging lung.

Original languageEnglish (US)
Pages (from-to)473-490
Number of pages18
JournalClinics in Geriatric Medicine
Issue number4
StatePublished - Nov 2017
Externally publishedYes


  • Aging
  • COPD
  • Cellular senescence
  • Idiopathic pulmonary fibrosis
  • Stem cells

ASJC Scopus subject areas

  • Geriatrics and Gerontology


Dive into the research topics of 'Lung Diseases of the Elderly: Cellular Mechanisms'. Together they form a unique fingerprint.

Cite this