TY - JOUR
T1 - Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood
AU - Polverino, Francesca
AU - Stern, Debra A.
AU - Snyder, Eric M.
AU - Wheatley-Guy, Courtney
AU - Bhatt, Surya P.
AU - Martinez, Fernando D.
AU - Guerra, Stefano
AU - Morgan, Wayne J.
N1 - Funding Information:
FP is supported by NIH grant RO1 HL149744, has received an unrestricted grant from Boehringer Ingelheim and is section editor for the European Respiratory Journal. SPB is supported by NIH grants R01HL151421 and UH3HL155806. He has received consulting fees from Boehringer Ingelheim and Sanofi and CME fees from IntegrityCE. S. Guerra, D. A. Stern, W. J. Morgan, and F. D. Martinez received support for this research from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) (grant no. 132523). S. Guerra reports grants from NIH/NHLBI, NIH/National Institute of Allergy and Infectious Diseases (NIAID), and the Cystic Fibrosis Foundation. W. J. Morgan reports grants from NIH/NHLBI, NIH/NIAID, and the Cystic Fibrosis Foundation; personal fees from the Cystic Fibrosis Foundation; and personal fees from Genentech. F. D. Martinez reports grants from NIH/NHLBI, NIH/NIAID, NIH/National Institute of Environmental Health Sciences, NIH/Office of the Director, and Johnson & Johnson. He was also a consultant for Commense INC and Copeval. The rest of the authors declare that they have no relevant conflicts of interest.This study was supported by awards AI135108 from National Institute of Allergy and Infectious Diseases and HL132523 from National Heart, Lung, and Blood Institute, US National Institutes of Health. We gratefully acknowledge the contributions of Lynn M. Taussig who started the Tucson Children's Respiratory Study in 1980. We thank Per M. Gustafsson for assistance with MBW measurements, and our study nurses and technicians for data collection and participant follow-up. We would like to thank the TCRS study participants and their parents for their continued support and enthusiasm.
Funding Information:
This study was supported by awards AI135108 from National Institute of Allergy and Infectious Diseases and HL132523 from National Heart, Lung, and Blood Institute , US National Institutes of Health . We gratefully acknowledge the contributions of Lynn M. Taussig who started the Tucson Children's Respiratory Study in 1980. We thank Per M. Gustafsson for assistance with MBW measurements, and our study nurses and technicians for data collection and participant follow-up. We would like to thank the TCRS study participants and their parents for their continued support and enthusiasm.
Publisher Copyright:
© 2022 The Author(s)
PY - 2023/1
Y1 - 2023/1
N2 - Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we evaluated the parameters from computed tomography (CT) scans performed at the age of 26 years in 39 subjects from the birth cohort of the Tucson Children's Respiratory Study (TCRS) in order to determine the relationship between early childhood factors and lung structural changes in young adult life. We found that participants with LRIs in childhood had increased air trapping at the age of 26 suggesting an association between childhood infections and lung development.
AB - Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we evaluated the parameters from computed tomography (CT) scans performed at the age of 26 years in 39 subjects from the birth cohort of the Tucson Children's Respiratory Study (TCRS) in order to determine the relationship between early childhood factors and lung structural changes in young adult life. We found that participants with LRIs in childhood had increased air trapping at the age of 26 suggesting an association between childhood infections and lung development.
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U2 - 10.1016/j.rmed.2022.107062
DO - 10.1016/j.rmed.2022.107062
M3 - Article
C2 - 36508986
AN - SCOPUS:85143989208
SN - 0954-6111
VL - 206
JO - British Journal of Tuberculosis and Diseases of the Chest
JF - British Journal of Tuberculosis and Diseases of the Chest
M1 - 107062
ER -