Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood

Francesca Polverino; Debra A. Stern; Eric M. Snyder; Courtney Wheatley-Guy; Surya P. Bhatt; Fernando D. Martinez; Stefano Guerra; Wayne J. Morgan

doi:10.1016/j.rmed.2022.107062

Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood

Francesca Polverino, Debra A. Stern, Eric M. Snyder, Courtney Wheatley-Guy, Surya P. Bhatt, Fernando D. Martinez, Stefano Guerra, Wayne J. Morgan

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we evaluated the parameters from computed tomography (CT) scans performed at the age of 26 years in 39 subjects from the birth cohort of the Tucson Children's Respiratory Study (TCRS) in order to determine the relationship between early childhood factors and lung structural changes in young adult life. We found that participants with LRIs in childhood had increased air trapping at the age of 26 suggesting an association between childhood infections and lung development.

Original language	English (US)
Article number	107062
Journal	Respiratory Medicine
Volume	206
DOIs	https://doi.org/10.1016/j.rmed.2022.107062
State	Published - Jan 2023

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.rmed.2022.107062

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title = "Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood",

abstract = "Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we evaluated the parameters from computed tomography (CT) scans performed at the age of 26 years in 39 subjects from the birth cohort of the Tucson Children's Respiratory Study (TCRS) in order to determine the relationship between early childhood factors and lung structural changes in young adult life. We found that participants with LRIs in childhood had increased air trapping at the age of 26 suggesting an association between childhood infections and lung development.",

author = "Francesca Polverino and Stern, {Debra A.} and Snyder, {Eric M.} and Courtney Wheatley-Guy and Bhatt, {Surya P.} and Martinez, {Fernando D.} and Stefano Guerra and Morgan, {Wayne J.}",

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doi = "10.1016/j.rmed.2022.107062",

language = "English (US)",

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T1 - Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood

AU - Polverino, Francesca

AU - Stern, Debra A.

AU - Snyder, Eric M.

AU - Wheatley-Guy, Courtney

AU - Bhatt, Surya P.

AU - Martinez, Fernando D.

AU - Guerra, Stefano

AU - Morgan, Wayne J.

PY - 2023/1

Y1 - 2023/1

N2 - Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we evaluated the parameters from computed tomography (CT) scans performed at the age of 26 years in 39 subjects from the birth cohort of the Tucson Children's Respiratory Study (TCRS) in order to determine the relationship between early childhood factors and lung structural changes in young adult life. We found that participants with LRIs in childhood had increased air trapping at the age of 26 suggesting an association between childhood infections and lung development.

AB - Several factors occurring in early life, including lower respiratory tract illnesses (LRIs), are involved in determining lung structure and function in adulthood, but the effects of these factors on lung development remain largely unknown. Hereby, we evaluated the parameters from computed tomography (CT) scans performed at the age of 26 years in 39 subjects from the birth cohort of the Tucson Children's Respiratory Study (TCRS) in order to determine the relationship between early childhood factors and lung structural changes in young adult life. We found that participants with LRIs in childhood had increased air trapping at the age of 26 suggesting an association between childhood infections and lung development.

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Lower respiratory illnesses in childhood are associated with the presence of air trapping in early adulthood

Abstract

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