Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery

Jang Kyoung Kim; Young Wook Won; Kwang Suk Lim; Yong Hee Kim

doi:10.1007/s11095-011-0581-8

Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery

Jang Kyoung Kim, Young Wook Won, Kwang Suk Lim, Yong Hee Kim

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Purpose: To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX). Methods: LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model. Results: Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40° C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX. Conclusions: The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.

Original language	English (US)
Pages (from-to)	525-534
Number of pages	10
Journal	Pharmaceutical Research
Volume	29
Issue number	2
DOIs	https://doi.org/10.1007/s11095-011-0581-8
State	Published - Feb 2012
Externally published	Yes

Keywords

Cancer therapy
Docetaxel
Drug delivery
Gel/micelle combination system
Methylcellulose

ASJC Scopus subject areas

Biotechnology
Molecular Medicine
Pharmacology
Pharmaceutical Science
Organic Chemistry
Pharmacology (medical)

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10.1007/s11095-011-0581-8

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title = "Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery",

abstract = "Purpose: To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX). Methods: LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model. Results: Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40° C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX. Conclusions: The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.",

keywords = "Cancer therapy, Docetaxel, Drug delivery, Gel/micelle combination system, Methylcellulose",

author = "Kim, {Jang Kyoung} and Won, {Young Wook} and Lim, {Kwang Suk} and Kim, {Yong Hee}",

note = "Funding Information: This research was partially supported by grants from the Korea Science and Engineering Foundation (20110017022), WCU (World Class University) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R332010000100360), Yang Young Foundation and Seoul R&BD program (ST100071M093211).",

year = "2012",

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doi = "10.1007/s11095-011-0581-8",

language = "English (US)",

volume = "29",

pages = "525--534",

journal = "Pharmaceutical Research",

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T1 - Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery

AU - Kim, Jang Kyoung

AU - Won, Young Wook

AU - Lim, Kwang Suk

AU - Kim, Yong Hee

N1 - Funding Information: This research was partially supported by grants from the Korea Science and Engineering Foundation (20110017022), WCU (World Class University) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R332010000100360), Yang Young Foundation and Seoul R&BD program (ST100071M093211).

PY - 2012/2

Y1 - 2012/2

N2 - Purpose: To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX). Methods: LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model. Results: Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40° C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX. Conclusions: The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.

AB - Purpose: To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX). Methods: LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model. Results: Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40° C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX. Conclusions: The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.

KW - Cancer therapy

KW - Docetaxel

KW - Drug delivery

KW - Gel/micelle combination system

KW - Methylcellulose

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Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery

Abstract

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