Low-molecular-weight methylcellulose-based thermo-reversible gel/pluronic micelle combination system for local and sustained docetaxel delivery

Jang Kyoung Kim, Young Wook Won, Kwang Suk Lim, Yong Hee Kim

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Purpose: To develop low-molecular-weight methylcellulose (LMw MC)-based gel/Pluronic F127 micelle combination system for local and sustained delivery of docetaxel (DTX). Methods: LMw MC and Pluronic F127 were used to formulate an injectable thermo-reversible gel/micelle combination system containing DTX. The DTX-loaded combination system was characterized and its therapeutic efficacy evaluated in a subcutaneous tumor model. Results: Mixtures of LMw MC, AS, and Pluronic F127 formed gel at ~15-40° C depending on AS concentration. The combination system released DTX for >30 days with a biphasic and sustained release pattern, and DTX stability was maintained during release. The combination system significantly enhanced anti-cancer effects of DTX and prolonged survival of the model mouse in comparison with free DTX. Conclusions: The LMw MC gel/Pluronic F127 micelle combination system constitutes a promising tool for reducing tumor size and eradicating remaining tumor cells before and after surgery.

Original languageEnglish (US)
Pages (from-to)525-534
Number of pages10
JournalPharmaceutical Research
Volume29
Issue number2
DOIs
StatePublished - Feb 2012
Externally publishedYes

Keywords

  • Cancer therapy
  • Docetaxel
  • Drug delivery
  • Gel/micelle combination system
  • Methylcellulose

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

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