Low intracellular iron increases the stability of Matriptase-2

Ningning Zhao; Christopher P. Nizzi; Sheila A. Anderson; Jiaohong Wang; Akiko Ueno; Hidekazu Tsukamoto; Richard S. Eisenstein; Caroline A. Enns; An Sheng Zhang

doi:10.1074/jbc.M114.611913

Low intracellular iron increases the stability of Matriptase-2

Ningning Zhao
, Christopher P. Nizzi
, Sheila A. Anderson
, Jiaohong Wang
, Akiko Ueno
, Hidekazu Tsukamoto
, Richard S. Eisenstein
, Caroline A. Enns
, An Sheng Zhang

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

Original language	English (US)
Pages (from-to)	4432-4446
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M114.611913
State	Published - Feb 13 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.611913

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title = "Low intracellular iron increases the stability of Matriptase-2",

abstract = "Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.",

author = "Ningning Zhao and Nizzi, \{Christopher P.\} and Anderson, \{Sheila A.\} and Jiaohong Wang and Akiko Ueno and Hidekazu Tsukamoto and Eisenstein, \{Richard S.\} and Enns, \{Caroline A.\} and Zhang, \{An Sheng\}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.",

year = "2015",

month = feb,

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doi = "10.1074/jbc.M114.611913",

language = "English (US)",

volume = "290",

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journal = "Journal of Biological Chemistry",

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TY - JOUR

T1 - Low intracellular iron increases the stability of Matriptase-2

AU - Zhao, Ningning

AU - Nizzi, Christopher P.

AU - Anderson, Sheila A.

AU - Wang, Jiaohong

AU - Ueno, Akiko

AU - Tsukamoto, Hidekazu

AU - Eisenstein, Richard S.

AU - Enns, Caroline A.

AU - Zhang, An Sheng

PY - 2015/2/13

Y1 - 2015/2/13

N2 - Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

AB - Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

UR - https://www.scopus.com/pages/publications/84922789739

UR - https://www.scopus.com/pages/publications/84922789739#tab=citedBy

U2 - 10.1074/jbc.M114.611913

DO - 10.1074/jbc.M114.611913

M3 - Article

C2 - 25550162

AN - SCOPUS:84922789739

SN - 0021-9258

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SP - 4432

EP - 4446

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

Low intracellular iron increases the stability of Matriptase-2

Abstract

ASJC Scopus subject areas

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