Abstract
Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.
Original language | English (US) |
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Pages (from-to) | 4432-4446 |
Number of pages | 15 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 7 |
DOIs | |
State | Published - Feb 13 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology