Low intracellular iron increases the stability of Matriptase-2

Ningning Zhao, Christopher P. Nizzi, Sheila A. Anderson, Jiaohong Wang, Akiko Ueno, Hidekazu Tsukamoto, Richard S. Eisenstein, Caroline A. Enns, An Sheng Zhang

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background: Matriptase-2 (MT2) is essential for iron homeostasis. The mechanism for its regulation is controversial. Results: The cytoplasmic domain of MT2 is necessary for its stabilization by iron depletion. MT2 expression is not regulated at either the transcriptional mRNA or translational level by iron. Conclusion: Depletion of cellular iron stabilizes MT2. Significance: Low iron levels in hepatocytes stabilize MT2 to suppress hepcidin expression.

Original languageEnglish (US)
Pages (from-to)4432-4446
Number of pages15
JournalJournal of Biological Chemistry
Issue number7
StatePublished - Feb 13 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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