TY - JOUR
T1 - Low diversity gut microbiota dysbiosis
T2 - drivers, functional implications and recovery
AU - Kriss, Michael
AU - Hazleton, Keith Z.
AU - Nusbacher, Nichole M.
AU - Martin, Casey G.
AU - Lozupone, Catherine A.
N1 - Funding Information:
This research was supported by the National Institutes of Health [grant number 5T32DK067009-12 ].
Publisher Copyright:
© 2018
PY - 2018/8
Y1 - 2018/8
N2 - Dysbiosis, an imbalance in microbial communities, is linked with disease when this imbalance disturbs microbiota functions essential for maintaining health or introduces processes that promote disease. Dysbiosis in disease is predicted when microbiota differ compositionally from a healthy control population, but only truly defined when these differences are mechanistically related to adverse phenotypes. For the human gut microbiota, dysbiosis varies across diseases. One common manifestation is replacement of the complex community of anaerobes typical of the healthy adult gut microbiome with a community of lower overall microbial diversity and increased facultative anaerobes. Here we review diseases in which low-diversity dysbiosis has been observed and mechanistically linked with disease, with a particular focus on liver disease, inflammatory bowel disease, and Clostridium difficile infection.
AB - Dysbiosis, an imbalance in microbial communities, is linked with disease when this imbalance disturbs microbiota functions essential for maintaining health or introduces processes that promote disease. Dysbiosis in disease is predicted when microbiota differ compositionally from a healthy control population, but only truly defined when these differences are mechanistically related to adverse phenotypes. For the human gut microbiota, dysbiosis varies across diseases. One common manifestation is replacement of the complex community of anaerobes typical of the healthy adult gut microbiome with a community of lower overall microbial diversity and increased facultative anaerobes. Here we review diseases in which low-diversity dysbiosis has been observed and mechanistically linked with disease, with a particular focus on liver disease, inflammatory bowel disease, and Clostridium difficile infection.
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U2 - 10.1016/j.mib.2018.07.003
DO - 10.1016/j.mib.2018.07.003
M3 - Review article
C2 - 30036705
AN - SCOPUS:85050140883
SN - 1369-5274
VL - 44
SP - 34
EP - 40
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -