Longitudinal diffusion tensor imaging in a rat brain glioma model

Silvia Lope-Piedrafita, Maria L. Garcia-Martin, Jean Philippe Galons, Robert J. Gillies, Theodore P. Trouard

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


In order to investigate the properties of water motion within and around brain tumors as a function of tumor growth, longitudinal diffusion tensor imaging (DTI) was carried out in a rat brain glioma (C6) model. As tumors grew in size, significant anisotropy of water diffusion was seen both within and around the tumor. The tissue water surrounding the tumor exhibited high planar anisotropy, as opposed to the linear anisotropy normally seen in white matter, indicating that cells were experiencing stress in a direction normal to the tumor border. When tumors were sufficiently large, significant anisotropy was also seen within the tumor because of longer-range organization of cancer cells within the tumor borders. These findings have important implications for diffusion-weighted MRI experiments examining tumor growth and response to therapy.

Original languageEnglish (US)
Pages (from-to)799-808
Number of pages10
JournalNMR in biomedicine
Issue number8
StatePublished - Oct 2008


  • Cancer
  • Diffusion tensor imaging (DTI)
  • Glioma
  • Rat

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


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