Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism

Markus Donix, Alison C. Burggren, Nanthia A. Suthana, Prabha Siddarth, Arne D. Ekstrom, Allison K. Krupa, Michael Jones, Anup Rao, Laurel Martin-Harris, Linda M. Ercoli, Karen J. Miller, Gary W. Small, Susan Y. Bookheimer

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


People with the apolipoprotein-Eε4 (APOE-4) genetic risk for Alzheimer's disease show morphologic differences in medial temporal lobe regions when compared to non-carriers of the allele. Using a high-resolution MRI and cortical unfolding approach, our aim was to determine the rate of cortical thinning among medial temporal lobe subregions over the course of 2 years. We hypothesized that APOE-4 genetic risk would contribute to longitudinal cortical thickness change in the subiculum and entorhinal cortex, regions preferentially susceptible to Alzheimer's disease related pathology. Thirty-two cognitively intact subjects, mean age 61 years, 16 APOE-4 carriers, 16 non-carriers, underwent baseline and follow-up MRI scans. Over this relatively brief interval, we found significantly greater cortical thinning in the subiculum and entorhinal cortex of APOE-4 carriers when compared to non-carriers of the allele. Average cortical thinning across all medial temporal lobe subregions combined was also significantly greater for APOE-4 carriers. This finding is consistent with the hypothesis that carrying the APOE-4 allele renders subjects at a higher risk for developing Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
Issue number1
StatePublished - Oct 2010
Externally publishedYes


  • APOE genotype
  • Alzheimer's disease
  • Cortical thickness
  • Cortical unfolding
  • High-resolution MRI
  • Medial temporal lobe

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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