Longevity as a Complex Genetic Trait

George L. Sutphin, Ron Korstanje

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Aging is influenced by many intrinsic and extrinsic factors including genetic background, epigenetics, diet, and environment. Our ability to develop a complete model of the aging process and accurately predict outcomes designed to extend lifespan or treat age-associated pathology requires identification of the range of factors capable of influence aging and an understanding of how these factors interact. In this chapter we discuss longevity and other phenotypes related to aging as complex genetic traits. We first review past and ongoing efforts to comprehensively catalog genetic and non-genetic factors that impact lifespan in invertebrate and mammalian model systems and conclude by discussing emerging tools that will help the aging-research community encompass the complexities of the aging process.

Original languageEnglish (US)
Title of host publicationHandbook of the Biology of Aging
Subtitle of host publicationEighth Edition
PublisherElsevier Inc.
Pages3-54
Number of pages52
ISBN (Electronic)9780124116207
ISBN (Print)9780124115965
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Complex trait
  • Gene mapping
  • Genomics
  • GWAS
  • Longevity
  • QTL

ASJC Scopus subject areas

  • General Psychology

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