Long-term synaptic enhancement in hippocampus is not regulated by postsynaptic membrane potential

H. Wigström; B. L. McNaughton; C. A. Barnes

doi:10.1016/0006-8993(82)90941-6

Long-term synaptic enhancement in hippocampus is not regulated by postsynaptic membrane potential

H. Wigström, B. L. McNaughton, C. A. Barnes

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The contributions of membrane potential and postsynaptic discharge during afferent fibre tetanization to the generation of long-lasting synaptic enhancement was studied by intra- and extracellular recording in the CA1 region of hippocampal slices. Neither parameter affected the magnitude of intracellular synaptic enhancement. Thus, if postsynaptic integration is involved in the control of the enhancement process, the integration must be chemically rather than electrically mediated.

Original language	English (US)
Pages (from-to)	195-199
Number of pages	5
Journal	Brain Research
Volume	233
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(82)90941-6
State	Published - Feb 4 1982
Externally published	Yes

Keywords

brain slice
hippocampus
membrane potential
pyramidal cells
rat
synaptic modification

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(82)90941-6

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AU - McNaughton, B. L.

AU - Barnes, C. A.

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AB - The contributions of membrane potential and postsynaptic discharge during afferent fibre tetanization to the generation of long-lasting synaptic enhancement was studied by intra- and extracellular recording in the CA1 region of hippocampal slices. Neither parameter affected the magnitude of intracellular synaptic enhancement. Thus, if postsynaptic integration is involved in the control of the enhancement process, the integration must be chemically rather than electrically mediated.

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KW - membrane potential

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KW - rat

KW - synaptic modification

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Long-term synaptic enhancement in hippocampus is not regulated by postsynaptic membrane potential

Abstract

Keywords

ASJC Scopus subject areas

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