Long term repair of learning disability through short-term reduction of CNS inhibition

H. Craig Heller, Damien Colas, Norman F. Ruby, Fabian Fernandez, Bayarasaikhan Chuluun, Martina Blank, Craig C. Garner

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Learning disabilities are serious societal problems contributing to a loss of quality of life for affected individuals and their families. We hypothesized that the learning disability in Down Syndrome and perhaps in other neurodegenerative disorders is due to an imbalance between inhibitory and excitatory tone in the CNS. Specifically, we predicted that reduction of GABA related inhibition would improve learning. We used the TsDn65 mouse model of Down Syndrome and treated adult mice with daily doses of different GABA antagonists. Following treatments learning performance of these mice in several rodent learning tasks was indistinguishable from the performance of wild type mice, and the learning improvement lasted for months after the treatment ended. We are now exploring the mechanism of this durable neuroplastic effect and asking whether it would generalize to other learning disorders or optimize learning in wild type mice.

Original languageEnglish (US)
Title of host publicationFoundations of Augmented Cognition
Subtitle of host publicationNeuroergonomics and Operational Neuroscience - 5th International Conference, FAC 2009, Held as Part of HCI International 2009, Proceedings
Pages818-825
Number of pages8
DOIs
StatePublished - 2009
Externally publishedYes
Event5th International Conference on Foundations of Augmented Cognition, FAC 2009, Held as Part of HCI International 2009 - San Diego, CA, United States
Duration: Jul 19 2009Jul 24 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5638 LNAI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference5th International Conference on Foundations of Augmented Cognition, FAC 2009, Held as Part of HCI International 2009
Country/TerritoryUnited States
CitySan Diego, CA
Period7/19/097/24/09

Keywords

  • Bilobilide
  • Down syndrome
  • Flumazinil
  • GABA
  • Novel object recognition
  • Pentylenetetrazole
  • Picrotoxin
  • TsDn65 mice

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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