Long-term potentiation and the ageing brain

C. A. Barnes

doi:10.1098/rstb.2002.1244

Long-term potentiation and the ageing brain

C. A. Barnes

Research output: Contribution to journal › Review article › peer-review

174 Scopus citations

Abstract

Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.

Original language	English (US)
Pages (from-to)	765-772
Number of pages	8
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	358
Issue number	1432
DOIs	https://doi.org/10.1098/rstb.2002.1244
State	Published - Apr 29 2003

Keywords

Ageing
Hippocampus
Learning
Long-term potentiation
Memory

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1098/rstb.2002.1244

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AB - Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.

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KW - Hippocampus

KW - Learning

KW - Long-term potentiation

KW - Memory

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Long-term potentiation and the ageing brain

Abstract

Keywords

ASJC Scopus subject areas

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