Long-term potentiation and the ageing brain

C. A. Barnes

doi:10.1098/rstb.2002.1244

Long-term potentiation and the ageing brain

C. A. Barnes

Research output: Contribution to journal › Review article › peer-review

162 Scopus citations

Abstract

Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.

Original language	English (US)
Pages (from-to)	765-772
Number of pages	8
Journal	Philosophical Transactions of the Royal Society B: Biological Sciences
Volume	358
Issue number	1432
DOIs	https://doi.org/10.1098/rstb.2002.1244
State	Published - Apr 29 2003

Keywords

Ageing
Hippocampus
Learning
Long-term potentiation
Memory

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

Access to Document

10.1098/rstb.2002.1244

Cite this

@article{fa9b64cefa364350a20fb8454816f5d2,

title = "Long-term potentiation and the ageing brain",

abstract = "Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.",

keywords = "Ageing, Hippocampus, Learning, Long-term potentiation, Memory",

author = "Barnes, {C. A.}",

year = "2003",

month = apr,

day = "29",

doi = "10.1098/rstb.2002.1244",

language = "English (US)",

volume = "358",

pages = "765--772",

journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",

issn = "0962-8436",

number = "1432",

}

TY - JOUR

T1 - Long-term potentiation and the ageing brain

AU - Barnes, C. A.

PY - 2003/4/29

Y1 - 2003/4/29

N2 - Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.

AB - Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.

KW - Ageing

KW - Hippocampus

KW - Learning

KW - Long-term potentiation

KW - Memory

UR - http://www.scopus.com/inward/record.url?scp=0038222582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038222582&partnerID=8YFLogxK

U2 - 10.1098/rstb.2002.1244

DO - 10.1098/rstb.2002.1244

M3 - Review article

C2 - 12740124

AN - SCOPUS:0038222582

SN - 0962-8436

VL - 358

SP - 765

EP - 772

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

IS - 1432

ER -

Long-term potentiation and the ageing brain

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this