Abstract
Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.
Original language | English (US) |
---|---|
Pages (from-to) | 765-772 |
Number of pages | 8 |
Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
Volume | 358 |
Issue number | 1432 |
DOIs | |
State | Published - Apr 29 2003 |
Keywords
- Ageing
- Hippocampus
- Learning
- Long-term potentiation
- Memory
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)