Abstract
Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 765-772 |
| Number of pages | 8 |
| Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
| Volume | 358 |
| Issue number | 1432 |
| DOIs | |
| State | Published - Apr 29 2003 |
Keywords
- Ageing
- Hippocampus
- Learning
- Long-term potentiation
- Memory
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)