Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy

Kimberly Smith, Evgenia Aga, Ronald J. Bosch, Hernan Valdez, Elizabeth Connick, Alan Landay, Daniel Kuritzkes, Barry H. Gross, Isaac R. Francis, Joseph M. McCune, Harold Kessler, Michael Lederman

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm 3 after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm3 and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm 3. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.

Original languageEnglish (US)
Pages (from-to)1953-1956
Number of pages4
JournalAIDS
Volume18
Issue number14
DOIs
StatePublished - Sep 24 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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