Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology

Sarath Babu Nukala, Jordan Jousma, Yoonje Cho, Won Hee Lee, Sang Ging Ong

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Cancer is one of the leading causes of morbidity and mortality worldwide. Significant improvements in the modern era of anticancer therapeutic strategies have increased the survival rate of cancer patients. Unfortunately, cancer survivors have an increased risk of cardiovascular diseases, which is believed to result from anticancer therapies. The emergence of cardiovascular diseases among cancer survivors has served as the basis for establishing a novel field termed cardio-oncology. Cardio-oncology primarily focuses on investigating the underlying molecular mechanisms by which anticancer treatments lead to cardiovascular dysfunction and the development of novel cardioprotective strategies to counteract cardiotoxic effects of cancer therapies. Advances in genome biology have revealed that most of the genome is transcribed into non-coding RNAs (ncRNAs), which are recognized as being instrumental in cancer, cardiovascular health, and disease. Emerging studies have demonstrated that alterations of these ncRNAs have pathophysiological roles in multiple diseases in humans. As it relates to cardio-oncology, though, there is limited knowledge of the role of ncRNAs. In the present review, we summarize the up-to-date knowledge regarding the roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in cancer therapy-induced cardiotoxicities. Moreover, we also discuss prospective therapeutic strategies and the translational relevance of these ncRNAs.

Original languageEnglish (US)
Article number24
JournalCell and Bioscience
Volume12
Issue number1
DOIs
StatePublished - Dec 2022
Externally publishedYes

Keywords

  • Cardio-oncology
  • Cardiotoxicity
  • LncRNAs
  • Non-coding RNAs
  • miRNAs

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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