Long COVID: a clinical update

Trisha Greenhalgh, Manoj Sivan, Alice Perlowski, Janko Nikolich

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Post-COVID-19 condition (also known as long COVID) is generally defined as symptoms persisting for 3 months or more after acute COVID-19. Long COVID can affect multiple organ systems and lead to severe and protracted impairment of function as a result of organ damage. The burden of this disease, both on the individual and on health systems and national economies, is high. In this interdisciplinary Review, with a coauthor with lived experience of severe long COVID, we sought to bring together multiple streams of literature on the epidemiology, pathophysiology (including the hypothesised mechanisms of organ damage), lived experience and clinical manifestations, and clinical investigation and management of long COVID. Although current approaches to long COVID care are largely symptomatic and supportive, recent advances in clinical phenotyping, deep molecular profiling, and biomarker identification might herald a more mechanism-informed and personally tailored approach to clinical care. We also cover the organisation of services for long COVID, approaches to preventing long COVID, and suggestions for future research.

Original languageEnglish (US)
Pages (from-to)707-724
Number of pages18
JournalThe Lancet
Volume404
Issue number10453
DOIs
StatePublished - Aug 17 2024
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine

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