Location-dependent change of median nerve mobility in the carpal tunnel of patients with carpal tunnel syndrome

Yifei Yao, Emily Grandy, Peter J. Evans, William H. Seitz, Zong Ming Li

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Introduction: The purpose of this study was to investigate in vivo median nerve longitudinal mobility in different segments of the carpal tunnel associated with active finger motion in carpal tunnel syndrome (CTS) patients in a comparison with healthy controls. Methods: Eleven healthy volunteers and 11 CTS patients participated in this study. Dynamic ultrasound images captured location-dependent longitudinal median nerve mobility within the carpal tunnel during finger flexion at the metacarpophalangeal joints using a speckle cross-correlation algorithm. Results: Median nerve longitudinal mobility in the carpal tunnel was significantly smaller in CTS patients (0.0037 ± 0.0011 mm/degree) compared with controls (0.0082 ± 0.0026 mm/degree) (P '.05), especially in the proximal (0.0064 vs 0.0132 mm/degree on average) and middle (0.0033 vs 0.0074 mm/degree on average) carpal tunnel sections. Discussion: Median nerve mobility can potentially serve as a biomechanical marker when diagnosing CTS, or when assessing the effectiveness of surgical and conservative treatments.

Original languageEnglish (US)
Pages (from-to)522-527
Number of pages6
JournalMuscle and Nerve
Issue number4
StatePublished - Oct 1 2020


  • carpal tunnel syndrome, cross-correlation speckle tracking, dynamic ultrasound, median nerve mobility

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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