TY - JOUR
T1 - Locally produced autoantibodies in cancer
AU - Centuori, Sara M.
AU - Bhattacharya, Deepta
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/3/31
Y1 - 2022/3/31
N2 - The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022).
AB - The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022).
UR - http://www.scopus.com/inward/record.url?scp=85127073903&partnerID=8YFLogxK
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U2 - 10.1016/j.cell.2022.03.006
DO - 10.1016/j.cell.2022.03.006
M3 - Comment/debate
C2 - 35364029
AN - SCOPUS:85127073903
SN - 0092-8674
VL - 185
SP - 1110
EP - 1111
JO - Cell
JF - Cell
IS - 7
ER -