Localization of V1a vasopressin receptor mRNA expression in cultured neurons, astroglia, and oligodendroglia of rat cerebral cortex

Rose S. Yamazaki, Qi Chen, Steven S. Schreiber, Roberta Diaz Brinton

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Previous studies suggested the existence of V1a vasopressin receptors (V1aR) in the cerebral cortex. Here, we investigated the cellular and regional localization of V1aR in the E18 rat cerebral cortex using RT-PCR and Southern blot analysis of V1aR mRNA derived from enriched cultures of neurons, astroglia, and oligodendroglia from four cortical regions (rostral, caudal, dorsal and ventral). V1aR mRNA was detected in each of the cell types within each of the regions studied. These data indicate that V1aR is broadly distributed throughout the cerebral cortex and suggest that vasopressin plays an important role in cortical functions.

Original languageEnglish (US)
Pages (from-to)138-140
Number of pages3
JournalMolecular Brain Research
Volume45
Issue number1
DOIs
StatePublished - Apr 1997
Externally publishedYes

Keywords

  • Astroglia
  • Cerebral cortex
  • Learning and memory
  • Neuron
  • Oligodendroglia
  • RT-PCR
  • Vasopressin receptor
  • mRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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