Localization of specific neurotensin binding sites in the rat adrenal gland

M. Goedert; P. W. Mantyh; S. P. Hunt; P. C. Emson

doi:10.1016/0006-8993(84)90726-1

Localization of specific neurotensin binding sites in the rat adrenal gland

M. Goedert, P. W. Mantyh, S. P. Hunt, P. C. Emson

Pharmacology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Specific tritiated neurotensin binding sites were localized in the rat adrenal gland by receptor autoradiography and characterized using a tissue homogenate receptor binding assay. High levels of specific neurotensin binding sites were found in the inner layer of the adrenal cortex and lower amounts in the adrenal medulla with only background labeling in the outer cortical layers. The structure-activity profile of the specific neurotensin binding was consistent with binding to a physiological neurotensin receptor.

Original language	English (US)
Pages (from-to)	389-392
Number of pages	4
Journal	Brain Research
Volume	299
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90726-1
State	Published - May 14 1984

Keywords

[H]neurotensin binding
adrenal cortex
adrenal medulla
receptor autoradiography

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90726-1

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AU - Mantyh, P. W.

AU - Hunt, S. P.

AU - Emson, P. C.

PY - 1984/5/14

Y1 - 1984/5/14

N2 - Specific tritiated neurotensin binding sites were localized in the rat adrenal gland by receptor autoradiography and characterized using a tissue homogenate receptor binding assay. High levels of specific neurotensin binding sites were found in the inner layer of the adrenal cortex and lower amounts in the adrenal medulla with only background labeling in the outer cortical layers. The structure-activity profile of the specific neurotensin binding was consistent with binding to a physiological neurotensin receptor.

AB - Specific tritiated neurotensin binding sites were localized in the rat adrenal gland by receptor autoradiography and characterized using a tissue homogenate receptor binding assay. High levels of specific neurotensin binding sites were found in the inner layer of the adrenal cortex and lower amounts in the adrenal medulla with only background labeling in the outer cortical layers. The structure-activity profile of the specific neurotensin binding was consistent with binding to a physiological neurotensin receptor.

KW - [H]neurotensin binding

KW - adrenal cortex

KW - adrenal medulla

KW - receptor autoradiography

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Localization of specific neurotensin binding sites in the rat adrenal gland

Abstract

Keywords

ASJC Scopus subject areas

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