Localization of choriocarcinoma by 131I-βHCG antibody

Kenneth D. Hatch, William J. Mann, Larry R. Boots, W. Newton Tauxe, Hugh M. Shingleton, Ernest S. Buchina

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A patient is presented who was cured surgically of metastatic gestational trophoblastic disease (GTD), of high-risk category, after the localization of tumor by radioactive antibody to HCG. The patient was initially treated with hysterectomy and resection of involved bowel; disease recurred, and conventional triple-agent chemotherapy failed, as well as less established multidrug reginens. Rabbit antibody to β-HCG was labeled with 131I and injected into the patient. Scintigrams localized the metastatic disease, allowing resection and cure. This methodology may offer a potential means of utilizing surgery to cure select patients who have failed triple-agent therapy and whose prognosis is poor if treated conventionally.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalGynecologic oncology
Issue number3
StatePublished - Dec 1980

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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