Localization of choriocarcinoma by 131I-βHCG antibody

Kenneth D. Hatch; William J. Mann; Larry R. Boots; W. Newton Tauxe; Hugh M. Shingleton; Ernest S. Buchina

doi:10.1016/0090-8258(80)90091-8

Localization of choriocarcinoma by ¹³¹I-βHCG antibody

Kenneth D. Hatch, William J. Mann, Larry R. Boots, W. Newton Tauxe, Hugh M. Shingleton, Ernest S. Buchina

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A patient is presented who was cured surgically of metastatic gestational trophoblastic disease (GTD), of high-risk category, after the localization of tumor by radioactive antibody to HCG. The patient was initially treated with hysterectomy and resection of involved bowel; disease recurred, and conventional triple-agent chemotherapy failed, as well as less established multidrug reginens. Rabbit antibody to β-HCG was labeled with ¹³¹I and injected into the patient. Scintigrams localized the metastatic disease, allowing resection and cure. This methodology may offer a potential means of utilizing surgery to cure select patients who have failed triple-agent therapy and whose prognosis is poor if treated conventionally.

Original language	English (US)
Pages (from-to)	253-261
Number of pages	9
Journal	Gynecologic oncology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/0090-8258(80)90091-8
State	Published - Dec 1980

ASJC Scopus subject areas

Oncology
Obstetrics and Gynecology

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10.1016/0090-8258(80)90091-8

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@article{644c3dcf1dad464db68d7e65784dda91,

title = "Localization of choriocarcinoma by 131I-βHCG antibody",

abstract = "A patient is presented who was cured surgically of metastatic gestational trophoblastic disease (GTD), of high-risk category, after the localization of tumor by radioactive antibody to HCG. The patient was initially treated with hysterectomy and resection of involved bowel; disease recurred, and conventional triple-agent chemotherapy failed, as well as less established multidrug reginens. Rabbit antibody to β-HCG was labeled with 131I and injected into the patient. Scintigrams localized the metastatic disease, allowing resection and cure. This methodology may offer a potential means of utilizing surgery to cure select patients who have failed triple-agent therapy and whose prognosis is poor if treated conventionally.",

author = "Hatch, {Kenneth D.} and Mann, {William J.} and Boots, {Larry R.} and Tauxe, {W. Newton} and Shingleton, {Hugh M.} and Buchina, {Ernest S.}",

note = "Funding Information: r Supported, in part, by the Comprehensive Cancer Center Core Support Grant CA-13148 and Gyn Cancer Education Grant CA-241 18. 2 Address reprint requests to Kenneth D. Hatch, M.D., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Station, Birmingham, Ala. 35294.",

year = "1980",

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doi = "10.1016/0090-8258(80)90091-8",

language = "English (US)",

volume = "10",

pages = "253--261",

journal = "Gynecologic oncology",

issn = "0090-8258",

publisher = "Academic Press Inc.",

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T1 - Localization of choriocarcinoma by 131I-βHCG antibody

AU - Hatch, Kenneth D.

AU - Mann, William J.

AU - Boots, Larry R.

AU - Tauxe, W. Newton

AU - Shingleton, Hugh M.

AU - Buchina, Ernest S.

N1 - Funding Information: r Supported, in part, by the Comprehensive Cancer Center Core Support Grant CA-13148 and Gyn Cancer Education Grant CA-241 18. 2 Address reprint requests to Kenneth D. Hatch, M.D., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University Station, Birmingham, Ala. 35294.

PY - 1980/12

Y1 - 1980/12

N2 - A patient is presented who was cured surgically of metastatic gestational trophoblastic disease (GTD), of high-risk category, after the localization of tumor by radioactive antibody to HCG. The patient was initially treated with hysterectomy and resection of involved bowel; disease recurred, and conventional triple-agent chemotherapy failed, as well as less established multidrug reginens. Rabbit antibody to β-HCG was labeled with 131I and injected into the patient. Scintigrams localized the metastatic disease, allowing resection and cure. This methodology may offer a potential means of utilizing surgery to cure select patients who have failed triple-agent therapy and whose prognosis is poor if treated conventionally.

AB - A patient is presented who was cured surgically of metastatic gestational trophoblastic disease (GTD), of high-risk category, after the localization of tumor by radioactive antibody to HCG. The patient was initially treated with hysterectomy and resection of involved bowel; disease recurred, and conventional triple-agent chemotherapy failed, as well as less established multidrug reginens. Rabbit antibody to β-HCG was labeled with 131I and injected into the patient. Scintigrams localized the metastatic disease, allowing resection and cure. This methodology may offer a potential means of utilizing surgery to cure select patients who have failed triple-agent therapy and whose prognosis is poor if treated conventionally.

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Localization of choriocarcinoma by ¹³¹I-βHCG antibody

Abstract

ASJC Scopus subject areas

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