TY - JOUR
T1 - Liver and other gastrointestinal cancers are frequent in Mexican Americans
AU - Garza, Ariana L.
AU - Vatcheva, Kristina P.
AU - Pan, Jen Jung
AU - Rahbar, Mohammad H.
AU - Fallon, Michael B.
AU - McCormick, Joseph B.
AU - Fisher-Hoch, Susan P.
N1 - Funding Information:
This work was supported by MD000170 P20 funded from the National Institute on Minority Health and Health Disparities (NIMHD), and the Centers for Clinical and Translational Science Award 1U54RR023417-01 from the National Center for Research Resources (NCRR).
Funding Information:
This work was supported by MD000170 P20 funded from the National Center on Minority Health and Health disparities (NCMHD), and the Centers for Clinical and Translational Science Award UL1 TR000371 from the National Center for Research Resources (NCRR).
Publisher Copyright:
© W. Montague Cobb-NMA Health Institute 2015.
PY - 2015/5/15
Y1 - 2015/5/15
N2 - Background Disease patterns in Mexican American health-disparity populations differ from larger US populations. Aims This study is aimed to determine frequency of gastrointestinal cancers in Mexican Americans. Methods We analyzed self-reported data from the Cameron County Hispanic Cohort where we find high rates of risk factors for cancer: obesity (48.5%) and diabetes (30.7%). Participants provided cancer histories about themselves and first- and second-degree relatives. Logistic regression models assessed risk factors. Frequencies of cancer sites were ranked and validated using concurrent age local cancer registry data. Results Among 9,249 individuals (participants and their relatives), there were 1,184 individuals with reports of cancer. Among cohort participants under 70 years of age, the most significant risk factor for all-cause cancers was diabetes (OR 3.57, 95% CI 1.32, 9.62). Participants with metabolic syndrome were significantly more likely to report cancer in relatives [1.73 (95% CI 1.26, 2.37]. Among cancers in fathers, liver cancer was ranked third, stomach fourth, colorectal sixth, and pancreas tenth. In mothers, stomach was third, liver fourth, colorectal seventh, and pancreas eleventh. The unusual prominence of these cancers in Mexican Americans, including liver cancer, was supported by age-adjusted incidence in local registry data. Conclusions Gastrointestinal system cancers, particularly, liver cancer, in a Mexican American health disparity cohort and their relatives rank higher than in other ethnicities and are associated with high rates of diabetes and metabolic syndrome. Effective prevention of diabetes and low-tech, high-quality screening strategies for gastrointestinal cancers are needed in health disparity communities.
AB - Background Disease patterns in Mexican American health-disparity populations differ from larger US populations. Aims This study is aimed to determine frequency of gastrointestinal cancers in Mexican Americans. Methods We analyzed self-reported data from the Cameron County Hispanic Cohort where we find high rates of risk factors for cancer: obesity (48.5%) and diabetes (30.7%). Participants provided cancer histories about themselves and first- and second-degree relatives. Logistic regression models assessed risk factors. Frequencies of cancer sites were ranked and validated using concurrent age local cancer registry data. Results Among 9,249 individuals (participants and their relatives), there were 1,184 individuals with reports of cancer. Among cohort participants under 70 years of age, the most significant risk factor for all-cause cancers was diabetes (OR 3.57, 95% CI 1.32, 9.62). Participants with metabolic syndrome were significantly more likely to report cancer in relatives [1.73 (95% CI 1.26, 2.37]. Among cancers in fathers, liver cancer was ranked third, stomach fourth, colorectal sixth, and pancreas tenth. In mothers, stomach was third, liver fourth, colorectal seventh, and pancreas eleventh. The unusual prominence of these cancers in Mexican Americans, including liver cancer, was supported by age-adjusted incidence in local registry data. Conclusions Gastrointestinal system cancers, particularly, liver cancer, in a Mexican American health disparity cohort and their relatives rank higher than in other ethnicities and are associated with high rates of diabetes and metabolic syndrome. Effective prevention of diabetes and low-tech, high-quality screening strategies for gastrointestinal cancers are needed in health disparity communities.
KW - Diabetes
KW - Gastrointestinal cancer
KW - Liver
KW - MexicanAmericans
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U2 - 10.1007/s40615-015-0104-0
DO - 10.1007/s40615-015-0104-0
M3 - Article
C2 - 26896100
AN - SCOPUS:85015266500
VL - 3
SP - 1
EP - 10
JO - Journal of racial and ethnic health disparities
JF - Journal of racial and ethnic health disparities
SN - 2197-3792
IS - 1
ER -