TY - JOUR
T1 - Lipid mediators of angiogenesis and the signalling pathways they initiate
AU - English, Denis
AU - Brindley, David N.
AU - Spiegel, Sarah
AU - Garcia, Joe G.N.
N1 - Funding Information:
This work was supported by grants from the NIH, grant #R01 HL 61751 awarded to DE and DNB, PO1 HL 58064 awarded to JGNG and DE, grants from the Methodist Heart Institute, the Methodist Schowalter Foundation, the Methodist Hospital Cancer Center and the Phi Beta Psi Sorority awarded to DE. DNB was supported by grants from the Canadian Institutes of Health Research, Heart and Stroke Foundation of Canada, Canadian Diabetes Foundation, the USA NIH. SS was supported by NIH grant #GM 43880, and JGNG was further supported by NIH grant #HL 69340.
PY - 2002/5/23
Y1 - 2002/5/23
N2 - Investigations carried out over the past 3 years have implicated a key role for sphingosine 1-phosphate (SPP) in angiogenesis and blood vessel maturation. SPP is capable of inducing almost every aspect of angiogenesis and vessel maturation in vitro, including endothelial cell chemotaxis, survival, proliferation, capillary morphogenesis and adherence antigen deployment, as well as stabilizing developing endothelial cell monolayers and recruitment of smooth muscle cells to maturing vessels. Acting in conjunction with protein angiogenic factors, SPP induces prolific vascular development in many established models of angiogenesis in vivo. Thus, SPP is a unique, potent and multifaceted angiogenic agent. While SPP induces angiogenic effects by ligating members of the endothelial differentiation gene (EDG) G-protein-coupled family of receptors, recent studies suggest that endogenously produced SPP may also account for the ability of tyrosine kinase receptors to induce cell migration. Thus, SPP provides a clear link between tyrosine kinase and G-protein-coupled receptor agonists involved in the angiogenic response. However, the mechanisms by which SPP exerts its effects on vascular cells remain unclear, conflicting and controversial. Precise definition of the signalling pathways by which SPP induces specific aspects of the angiogenic response promises to lead to new and effective therapeutic approaches to regulate angiogenesis at sites of tissue damage, neoplastic transformation and inflammation. This review will trace the discovery of SPP as a novel angiogenic factor as it outlines present information on the signalling pathways by which SPP induces its effects on cells of the developing vascular bed.
AB - Investigations carried out over the past 3 years have implicated a key role for sphingosine 1-phosphate (SPP) in angiogenesis and blood vessel maturation. SPP is capable of inducing almost every aspect of angiogenesis and vessel maturation in vitro, including endothelial cell chemotaxis, survival, proliferation, capillary morphogenesis and adherence antigen deployment, as well as stabilizing developing endothelial cell monolayers and recruitment of smooth muscle cells to maturing vessels. Acting in conjunction with protein angiogenic factors, SPP induces prolific vascular development in many established models of angiogenesis in vivo. Thus, SPP is a unique, potent and multifaceted angiogenic agent. While SPP induces angiogenic effects by ligating members of the endothelial differentiation gene (EDG) G-protein-coupled family of receptors, recent studies suggest that endogenously produced SPP may also account for the ability of tyrosine kinase receptors to induce cell migration. Thus, SPP provides a clear link between tyrosine kinase and G-protein-coupled receptor agonists involved in the angiogenic response. However, the mechanisms by which SPP exerts its effects on vascular cells remain unclear, conflicting and controversial. Precise definition of the signalling pathways by which SPP induces specific aspects of the angiogenic response promises to lead to new and effective therapeutic approaches to regulate angiogenesis at sites of tissue damage, neoplastic transformation and inflammation. This review will trace the discovery of SPP as a novel angiogenic factor as it outlines present information on the signalling pathways by which SPP induces its effects on cells of the developing vascular bed.
KW - Angiogenesis
KW - Endothelial cell
KW - Lipid mediator
KW - Smooth muscle cell
KW - Sphingosine 1-phosphate
KW - Vascular development
UR - http://www.scopus.com/inward/record.url?scp=0037162031&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037162031&partnerID=8YFLogxK
U2 - 10.1016/S1388-1981(02)00176-2
DO - 10.1016/S1388-1981(02)00176-2
M3 - Review article
C2 - 12069833
AN - SCOPUS:0037162031
SN - 1388-1981
VL - 1582
SP - 228
EP - 239
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 1-3
ER -