Lipid-Based Nanotechnology: Liposome

Yanhao Jiang, Wenpan Li, Zhiren Wang, Jianqin Lu

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Over the past several decades, liposomes have been extensively developed and used for various clinical applications such as in pharmaceutical, cosmetic, and dietetic fields, due to its versatility, biocompatibility, and biodegradability, as well as the ability to enhance the therapeutic index of free drugs. However, some challenges remain unsolved, including liposome premature leakage, manufacturing irreproducibility, and limited translation success. This article reviews various aspects of liposomes, including its advantages, major compositions, and common preparation techniques, and discusses present U.S. FDA-approved, clinical, and preclinical liposomal nanotherapeutics for treating and preventing a variety of human diseases. In addition, we summarize the significance of and challenges in liposome-enabled nanotherapeutic development and hope it provides the fundamental knowledge and concepts about liposomes and their applications and contributions in contemporary pharmaceutical advancement.

Original languageEnglish (US)
Article number34
JournalPharmaceutics
Volume16
Issue number1
DOIs
StatePublished - Jan 2024

Keywords

  • disease treatments
  • drug delivery
  • liposome

ASJC Scopus subject areas

  • Pharmaceutical Science

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