Linkage of adrenoleukodystrophy to a polymorphic DNA probe

Patrick R. Aubourg, George H. Sack, Deborah A. Meyers, John J. Lease, Hugo W. Moser

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Linkage studies between X‐linked adrenoleukodystrophy and a cloned deoxyribonucleic acid fragment (St14), which detects polymorphisms in the distal end of the long arm of the X chromosome (Xq27–28), have shown no recombination in six families. The lod score for these data (and another kindred reported earlier) [2] is 13.766 at recombination fraction (θ) = 0.0. These data permit assignment of adrenoleukodystrophy carrier status in family members at risk, supplementing the chemical measurement of very‐long‐chain fatty acids.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalAnnals of Neurology
Volume21
Issue number4
DOIs
StatePublished - Apr 1987
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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