Linkage of adrenoleukodystrophy to a polymorphic DNA probe

Patrick R. Aubourg; George H. Sack; Deborah A. Meyers; John J. Lease; Hugo W. Moser

doi:10.1002/ana.410210406

Linkage of adrenoleukodystrophy to a polymorphic DNA probe

Patrick R. Aubourg, George H. Sack, Deborah A. Meyers, John J. Lease, Hugo W. Moser

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Linkage studies between X‐linked adrenoleukodystrophy and a cloned deoxyribonucleic acid fragment (St14), which detects polymorphisms in the distal end of the long arm of the X chromosome (Xq27–28), have shown no recombination in six families. The lod score for these data (and another kindred reported earlier) [2] is 13.766 at recombination fraction (θ) = 0.0. These data permit assignment of adrenoleukodystrophy carrier status in family members at risk, supplementing the chemical measurement of very‐long‐chain fatty acids.

Original language	English (US)
Pages (from-to)	349-352
Number of pages	4
Journal	Annals of Neurology
Volume	21
Issue number	4
DOIs	https://doi.org/10.1002/ana.410210406
State	Published - Apr 1987
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Linkage of adrenoleukodystrophy to a polymorphic DNA probe",

abstract = "Linkage studies between X‐linked adrenoleukodystrophy and a cloned deoxyribonucleic acid fragment (St14), which detects polymorphisms in the distal end of the long arm of the X chromosome (Xq27–28), have shown no recombination in six families. The lod score for these data (and another kindred reported earlier) [2] is 13.766 at recombination fraction (θ) = 0.0. These data permit assignment of adrenoleukodystrophy carrier status in family members at risk, supplementing the chemical measurement of very‐long‐chain fatty acids.",

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AU - Aubourg, Patrick R.

AU - Sack, George H.

AU - Meyers, Deborah A.

AU - Lease, John J.

AU - Moser, Hugo W.

PY - 1987/4

Y1 - 1987/4

N2 - Linkage studies between X‐linked adrenoleukodystrophy and a cloned deoxyribonucleic acid fragment (St14), which detects polymorphisms in the distal end of the long arm of the X chromosome (Xq27–28), have shown no recombination in six families. The lod score for these data (and another kindred reported earlier) [2] is 13.766 at recombination fraction (θ) = 0.0. These data permit assignment of adrenoleukodystrophy carrier status in family members at risk, supplementing the chemical measurement of very‐long‐chain fatty acids.

AB - Linkage studies between X‐linked adrenoleukodystrophy and a cloned deoxyribonucleic acid fragment (St14), which detects polymorphisms in the distal end of the long arm of the X chromosome (Xq27–28), have shown no recombination in six families. The lod score for these data (and another kindred reported earlier) [2] is 13.766 at recombination fraction (θ) = 0.0. These data permit assignment of adrenoleukodystrophy carrier status in family members at risk, supplementing the chemical measurement of very‐long‐chain fatty acids.

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JF - Annals of Neurology

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ER -

Linkage of adrenoleukodystrophy to a polymorphic DNA probe

Abstract

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