Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

A. A.Leslie Gunatilaka; Vanderlan Da S. Bolzani; Ermias Dagne; Glenn A. Hofmann; Randall K. Johnson; Francis L. McCabe; Michael R. Mattern; David G.I. Kingston

doi:10.1021/np9701687

Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

A. A.Leslie Gunatilaka
, Vanderlan Da S. Bolzani
, Ermias Dagne
, Glenn A. Hofmann
, Randall K. Johnson
, Francis L. McCabe
, Michael R. Mattern
, David G.I. Kingston

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, ¹³C NMR spectral assignments, and biological activities of these compounds are reported.

Original language	English (US)
Pages (from-to)	179-184
Number of pages	6
Journal	Journal Of Natural Products
Volume	61
Issue number	2
DOIs	https://doi.org/10.1021/np9701687
State	Published - Feb 1998

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np9701687

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title = "Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica",

abstract = "Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.",

author = "Gunatilaka, \{A. A.Leslie\} and Bolzani, \{Vanderlan Da S.\} and Ermias Dagne and Hofmann, \{Glenn A.\} and Johnson, \{Randall K.\} and McCabe, \{Francis L.\} and Mattern, \{Michael R.\} and Kingston, \{David G.I.\}",

year = "1998",

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doi = "10.1021/np9701687",

language = "English (US)",

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T1 - Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

AU - Gunatilaka, A. A.Leslie

AU - Bolzani, Vanderlan Da S.

AU - Dagne, Ermias

AU - Hofmann, Glenn A.

AU - Johnson, Randall K.

AU - McCabe, Francis L.

AU - Mattern, Michael R.

AU - Kingston, David G.I.

PY - 1998/2

Y1 - 1998/2

N2 - Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.

AB - Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.

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JO - Journal Of Natural Products

JF - Journal Of Natural Products

IS - 2

ER -

Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

Abstract

ASJC Scopus subject areas

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