TY - JOUR
T1 - Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica
AU - Gunatilaka, A. A.Leslie
AU - Bolzani, Vanderlan Da S.
AU - Dagne, Ermias
AU - Hofmann, Glenn A.
AU - Johnson, Randall K.
AU - McCabe, Francis L.
AU - Mattern, Michael R.
AU - Kingston, David G.I.
PY - 1998/2
Y1 - 1998/2
N2 - Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.
AB - Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.
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U2 - 10.1021/np9701687
DO - 10.1021/np9701687
M3 - Article
C2 - 9514005
AN - SCOPUS:0031905667
SN - 0163-3864
VL - 61
SP - 179
EP - 184
JO - Journal Of Natural Products
JF - Journal Of Natural Products
IS - 2
ER -