Limb salvage and prevention of ulcer recurrence in a chronic refractory diabetic foot osteomyelitis

Xiaoyan Jiang, Ning Li, Yi Yuan, Cheng Yang, Yan Chen, Yu Ma, Jianbai Wang, Dingyuan Du, Johnson Boey, David G. Armstrong, Wuquan Deng

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Biomechanical changes caused by structural foot deformities predispose patients to plantar ulceration. Plantar ulcer recurrence often leads to osteomyelitis, which is more commonly observed in patients with diabetes. Once the infection of diabetic foot ulcer (DFU) spreads and is complicated by osteomyelitis, treatment becomes more complicated and difficult. Osteomyelitis treatment remains challenging because of low drug concentration within the tissue caused by poor circulation and inadequate localized nutrition. Moreover, tissues around plantar ulcers are fewer and are thin, making the formation of granulation tissues difficult due to elevated plantar pressure. Furthermore, the skin around the wound is excessively keratinized, and the epidermis is hard to regenerate. Meanwhile, skin grafting at that site is often not successful due to poor blood circulation. Therefore, it is technically challenging to manage diabetic pressure plantar ulcer with osteomyelitis and prevent its recurrence. Here, we present a case of chronic DFU complicated by osteomyelitis due to foot deformity. The ulcer was successfully healed using advanced wound repair technology comprising of surgical bone resection, vancomycin-loaded bone cement implant, negativepressure wound therapy, and autologous platelet-rich gel. Subsequently, preventive foot care with custom-made offloading footwear was prescribed. The plantar ulcer did not recur and improvement in biomechanical parameters was observed after the intervention. This case represents an effective and comprehensive management strategy for limb salvage and prevention in patients with complicated foot conditions.

Original languageEnglish (US)
Pages (from-to)2289-2296
Number of pages8
JournalDiabetes, Metabolic Syndrome and Obesity
StatePublished - 2020


  • Antibiotic-loaded bone cement
  • Autologous platelet-rich gel
  • Diabetic foot ulcer
  • Negative-pressure wound therapy
  • Offloading footwear
  • Osteomyelitis

ASJC Scopus subject areas

  • Internal Medicine
  • Pharmacology


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