Light microscopic autoradiographic visualization of [3H]-arginine vasopressin binding sites in rat brain

Henry I. Yamamura; Kelvin W. Gee; Roberta E. Brinton; Thomas P. Davis; Mac Hadley; James K. Wamsley

doi:10.1016/0024-3205(83)90072-3

Light microscopic autoradiographic visualization of [³H]-arginine vasopressin binding sites in rat brain

Henry I. Yamamura
, Kelvin W. Gee
, Roberta E. Brinton
, Thomas P. Davis
, Mac Hadley
, James K. Wamsley

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Specific [³H]-arginine vasopressin ([³H]-AVP) binding sites were identified in the rat brain by light microscopic autoradiography. Discrete intrahypothalamic nuclei were densely labelled by [³H]-AVP. High specific binding was observed in the paraventricular and supraoptic nuclei. These binding sites may represent specific receptors for AVP, postulated to exist in the mammalian central nervous system.

Original language	English (US)
Pages (from-to)	1919-1924
Number of pages	6
Journal	Life Sciences
Volume	32
Issue number	16
DOIs	https://doi.org/10.1016/0024-3205(83)90072-3
State	Published - Apr 18 1983

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/0024-3205(83)90072-3

Cite this

@article{93e996a6770d4fb7a826031946128ce4,

title = "Light microscopic autoradiographic visualization of [3H]-arginine vasopressin binding sites in rat brain",

abstract = "Specific [3H]-arginine vasopressin ([3H]-AVP) binding sites were identified in the rat brain by light microscopic autoradiography. Discrete intrahypothalamic nuclei were densely labelled by [3H]-AVP. High specific binding was observed in the paraventricular and supraoptic nuclei. These binding sites may represent specific receptors for AVP, postulated to exist in the mammalian central nervous system.",

author = "Yamamura, \{Henry I.\} and Gee, \{Kelvin W.\} and Brinton, \{Roberta E.\} and Davis, \{Thomas P.\} and Mac Hadley and Wamsley, \{James K.\}",

note = "Funding Information: We thank Ms. Alice Landau for secretarial assistance. Part of this work was supported by Public Health Service Grants MH-27257 and MH-30626. K.W.G. is a recipient of a NRSA (NS-06923) from the National Institute of Neurological and Communicative Disorders and Stroke. R.E.B. is a recipient of a Predoctoral Research Fellowship Award (MH-08941) from the National Institute of Mental Health. H.I.Y. is a recipient of a USPHS Research Scientist Development Award, Type II (MH-00095), from the National Institute of Mental Health.",

year = "1983",

month = apr,

day = "18",

doi = "10.1016/0024-3205(83)90072-3",

language = "English (US)",

volume = "32",

pages = "1919--1924",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "16",

}

TY - JOUR

T1 - Light microscopic autoradiographic visualization of [3H]-arginine vasopressin binding sites in rat brain

AU - Yamamura, Henry I.

AU - Gee, Kelvin W.

AU - Brinton, Roberta E.

AU - Davis, Thomas P.

AU - Hadley, Mac

AU - Wamsley, James K.

N1 - Funding Information: We thank Ms. Alice Landau for secretarial assistance. Part of this work was supported by Public Health Service Grants MH-27257 and MH-30626. K.W.G. is a recipient of a NRSA (NS-06923) from the National Institute of Neurological and Communicative Disorders and Stroke. R.E.B. is a recipient of a Predoctoral Research Fellowship Award (MH-08941) from the National Institute of Mental Health. H.I.Y. is a recipient of a USPHS Research Scientist Development Award, Type II (MH-00095), from the National Institute of Mental Health.

PY - 1983/4/18

Y1 - 1983/4/18

N2 - Specific [3H]-arginine vasopressin ([3H]-AVP) binding sites were identified in the rat brain by light microscopic autoradiography. Discrete intrahypothalamic nuclei were densely labelled by [3H]-AVP. High specific binding was observed in the paraventricular and supraoptic nuclei. These binding sites may represent specific receptors for AVP, postulated to exist in the mammalian central nervous system.

AB - Specific [3H]-arginine vasopressin ([3H]-AVP) binding sites were identified in the rat brain by light microscopic autoradiography. Discrete intrahypothalamic nuclei were densely labelled by [3H]-AVP. High specific binding was observed in the paraventricular and supraoptic nuclei. These binding sites may represent specific receptors for AVP, postulated to exist in the mammalian central nervous system.

UR - https://www.scopus.com/pages/publications/0020967888

UR - https://www.scopus.com/pages/publications/0020967888#tab=citedBy

U2 - 10.1016/0024-3205(83)90072-3

DO - 10.1016/0024-3205(83)90072-3

M3 - Article

C2 - 6300592

AN - SCOPUS:0020967888

SN - 0024-3205

VL - 32

SP - 1919

EP - 1924

JO - Life Sciences

JF - Life Sciences

IS - 16

ER -

Light microscopic autoradiographic visualization of [³H]-arginine vasopressin binding sites in rat brain

Abstract

ASJC Scopus subject areas

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