Ligand-free Cu-catalyzed [3 + 2] cyclization for the synthesis of pyrrolo[1,2-a] quinolines with ambient air as a terminal oxidant

Yang Yu, Yuan Liu, Aoxia Liu, Hexin Xie, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

A ligand-free Cu-catalyzed [3 + 2] cycloaddition of ethyl 2-(quinolin-2-yl)acetates, ethyl 2-(isoquinolin-1-yl)acetates, and ethyl 2-(pyridin-2-yl)acetates with (E)-chalcones for a "one-pot" synthesis of pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines and indolizines has been developed. The annulation products were isolated in moderate to good yields with air as the sole oxidant under mild conditions.

Original languageEnglish (US)
Pages (from-to)7455-7458
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number31
DOIs
StatePublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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