TY - JOUR
T1 - Lifetime occupational exposure to dusts, gases and fumes is associated with bronchitis symptoms and higher diffusion capacity in COPD patients
AU - Rodríguez, Esther
AU - Ferrer, Jaume
AU - Zock, Jan Paul
AU - Serra, Ignasi
AU - Antó, Josep M.
AU - De Batlle, Jordi
AU - Kromhout, Hans
AU - Vermeulen, Roel
AU - Donaire-González, David
AU - Benet, Marta
AU - Balcells, Eva
AU - Monsó, Eduard
AU - Gayete, Àngel
AU - Garcia-Aymerich, Judith
AU - Guerra, Stefano
AU - Gea, Joaquim
AU - Orozco-Levi, Mauricio
AU - Vollmer, Ivan
AU - Barberà, Joan Albert
AU - Gómez, Federico P.
AU - Paré, Carles
AU - Roca, Josep
AU - Rodriguez-Roisin, Robert
AU - Agustí, Àlvar
AU - Freixa, Xavier
AU - Rodriguez, Diego A.
AU - Gimeno, Elena
AU - Portillo, Karina
AU - Andreu, Jordi
AU - Pallissa, Esther
AU - Casan, Pere
AU - Güell, Rosa
AU - Giménez, Ana
AU - Marín, Alicia
AU - Morera, Josep
AU - Farrero, Eva
AU - Escarrabill, Joan
AU - Ferrer, Antoni
AU - Sauleda, Jaume
AU - Togores, Bernat
AU - Gáldiz, Juan Bautista
AU - López, Lorena
AU - Belda, José
N1 - Funding Information:
Jaume Ferrer has received financial support from Almirall, Glaxo Smithkline, Novartis, Menarini, Nycomed and Boehringer Ingelheim for scientific meetings, research grants, advisory boards and scientific talks. Esther Rodríguez has received financial support from Novartis for scientific meetings and talks. This study was partly funded by Novartis Farmacèutica, Spain. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.
PY - 2014/2/6
Y1 - 2014/2/6
N2 - Background: Occupational exposure to dusts, gases and fumes has been associated with reduced FEV1 and sputum production in COPD patients. The effect of occupational exposure on other characteristics of COPD, especially those reflecting emphysema, has not been studied in these patients. Methods: We studied 338 patients hospitalized for a first exacerbation of COPD in 9 Spanish hospitals, obtaining full occupational history in a face-to-face interview; job codes were linked to a job exposure matrix for semi-quantitative estimation of exposure to mineral/biological dust, and gases/fumes for each job held. Patients underwent spirometry, diffusing capacity testing and analysis of gases in stable conditions. Quality of life, dyspnea and chronic bronchitis symptoms were determined with a questionnaire interview. A high- resolution CT scan was available in 133 patients. Results: 94% of the patients included were men, with a mean age of 68(8.5) years and a mean FEV1% predicted 52 (16). High exposure to gases or fumes was associated with chronic bronchitis, and exposure to mineral dust and gases/fumes was associated with higher scores for symptom perception in the St. George's questionnaire. No occupational agent was associated with a lower FEV1. High exposure to all occupational agents was associated with better lung diffusion capacity, in long-term quitters. In the subgroup with CT data, patients with emphysema had 18% lower DLCO compared to those without emphysema. Conclusions: In our cohort of COPD patients, high exposure to gases or fumes was associated with chronic bronchitis, and high exposure to all occupational agents was consistently associated with better diffusion capacity in long-term quitters.
AB - Background: Occupational exposure to dusts, gases and fumes has been associated with reduced FEV1 and sputum production in COPD patients. The effect of occupational exposure on other characteristics of COPD, especially those reflecting emphysema, has not been studied in these patients. Methods: We studied 338 patients hospitalized for a first exacerbation of COPD in 9 Spanish hospitals, obtaining full occupational history in a face-to-face interview; job codes were linked to a job exposure matrix for semi-quantitative estimation of exposure to mineral/biological dust, and gases/fumes for each job held. Patients underwent spirometry, diffusing capacity testing and analysis of gases in stable conditions. Quality of life, dyspnea and chronic bronchitis symptoms were determined with a questionnaire interview. A high- resolution CT scan was available in 133 patients. Results: 94% of the patients included were men, with a mean age of 68(8.5) years and a mean FEV1% predicted 52 (16). High exposure to gases or fumes was associated with chronic bronchitis, and exposure to mineral dust and gases/fumes was associated with higher scores for symptom perception in the St. George's questionnaire. No occupational agent was associated with a lower FEV1. High exposure to all occupational agents was associated with better lung diffusion capacity, in long-term quitters. In the subgroup with CT data, patients with emphysema had 18% lower DLCO compared to those without emphysema. Conclusions: In our cohort of COPD patients, high exposure to gases or fumes was associated with chronic bronchitis, and high exposure to all occupational agents was consistently associated with better diffusion capacity in long-term quitters.
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U2 - 10.1371/journal.pone.0088426
DO - 10.1371/journal.pone.0088426
M3 - Article
C2 - 24516659
AN - SCOPUS:84895521518
SN - 1932-6203
VL - 9
JO - PLoS One
JF - PLoS One
IS - 2
M1 - e88426
ER -