Leuprolide vs. diethylstilboestrol: Effect on natural killer cells

R. J. Ablin, M. J. Gonder, J. M. Bartkus

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Recent studies suggest even low dosages of oestrogen currently used for treatment of prostate cancer increase cardiovascular morbidity. In addition, relapse following growth of hormone-insensitive cells, and the present observations of further evidence of immunosuppression demonstrated by the significant (p < 0.001) effect of DES on the lytic activity of natural killer cells vs. the negligible effect of the luteinizing - hormone - releasing - hormone, leuprolide (Lupron) raises concern that the palliative effects of oestrogen therapy are possibly further compromised by a reduction in immunosurveillance to tumour, or equally important, by a decreased capacity to cope with infectious agents.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalAnticancer research
Issue number1
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Leuprolide vs. diethylstilboestrol: Effect on natural killer cells'. Together they form a unique fingerprint.

Cite this