Lesion-symptom mapping in the study of spoken language understanding

Stephen M. Wilson

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Lesion-symptom mapping studies aim to make inferences about the functional neuroanatomy of spoken language understanding by investigating relationships between damage to different brain regions and the various speech perception and comprehension deficits that result. Voxel-based lesion-symptom mapping, voxel-based morphometry, and studies focused on specific cortical regions of interest or fibre pathways have all yielded insights regarding the localisation of different components of spoken language processing. Major challenges include the fact that brain damage rarely impacts just a single brain region or just a single processing component, and that neuroplasticity and recovery can complicate the interpretation of lesion-deficit correlations. Future studies involving large patient cohorts derived from multi-centre projects, and multivariate approaches to quantifying patterns of brain damage and patterns of linguistic deficits, will continue to yield new insights into the neural basis of spoken language understanding.

Original languageEnglish (US)
Pages (from-to)891-899
Number of pages9
JournalLanguage, Cognition and Neuroscience
Issue number7
StatePublished - Aug 9 2017
Externally publishedYes


  • Lesion-symptom mapping
  • language comprehension
  • magnetic resonance imaging
  • spoken language understanding
  • voxel-based morphometry

ASJC Scopus subject areas

  • Language and Linguistics
  • Experimental and Cognitive Psychology
  • Linguistics and Language
  • Cognitive Neuroscience


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