Lens permeability changes associated with metabolic inhibition by iodoacetate

N. A. Delamere; C. A. Paterson

doi:10.1016/S0014-4835(82)80039-0

Lens permeability changes associated with metabolic inhibition by iodoacetate

N. A. Delamere, C. A. Paterson

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Sodium iodoacetate (IAA) at 10^-3m was shown to cause a biphasic depolarization of the rabbit lens. The first portion of the depolarization was attributed to inhibition of the electrogenic sodium pump following depression of glycolysis. The larger second phase of lens depolarization, a transient increase both of lens conductance and ⁴²K efflux rate, all indicate that IAA influences lens membrane permeability characteristics. After 100 min exposure to IAA, the lens potential stabilized at -39 mV, and lens conductance and ⁴²K efflux rate stabilized at values close to the control values. These findings suggested that extended treatment with IAA increased the ratio of lens sodium to potassium permeability without increasing the overall leakiness of the lens.

Original language	English (US)
Pages (from-to)	797-802
Number of pages	6
Journal	Experimental eye research
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/S0014-4835(82)80039-0
State	Published - May 1982
Externally published	Yes

Keywords

calcium
electrolyte balance
membrane permeability
rabbit lens
sodium iodoacetate

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/S0014-4835(82)80039-0

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title = "Lens permeability changes associated with metabolic inhibition by iodoacetate",

abstract = "Sodium iodoacetate (IAA) at 10-3m was shown to cause a biphasic depolarization of the rabbit lens. The first portion of the depolarization was attributed to inhibition of the electrogenic sodium pump following depression of glycolysis. The larger second phase of lens depolarization, a transient increase both of lens conductance and 42K efflux rate, all indicate that IAA influences lens membrane permeability characteristics. After 100 min exposure to IAA, the lens potential stabilized at -39 mV, and lens conductance and 42K efflux rate stabilized at values close to the control values. These findings suggested that extended treatment with IAA increased the ratio of lens sodium to potassium permeability without increasing the overall leakiness of the lens.",

keywords = "calcium, electrolyte balance, membrane permeability, rabbit lens, sodium iodoacetate",

author = "Delamere, {N. A.} and Paterson, {C. A.}",

note = "Funding Information: This study was supported by USPHS Research Grant No. EY00506 from the National Eye Institute.",

year = "1982",

month = may,

doi = "10.1016/S0014-4835(82)80039-0",

language = "English (US)",

volume = "34",

pages = "797--802",

journal = "Experimental eye research",

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T1 - Lens permeability changes associated with metabolic inhibition by iodoacetate

AU - Delamere, N. A.

AU - Paterson, C. A.

N1 - Funding Information: This study was supported by USPHS Research Grant No. EY00506 from the National Eye Institute.

PY - 1982/5

Y1 - 1982/5

N2 - Sodium iodoacetate (IAA) at 10-3m was shown to cause a biphasic depolarization of the rabbit lens. The first portion of the depolarization was attributed to inhibition of the electrogenic sodium pump following depression of glycolysis. The larger second phase of lens depolarization, a transient increase both of lens conductance and 42K efflux rate, all indicate that IAA influences lens membrane permeability characteristics. After 100 min exposure to IAA, the lens potential stabilized at -39 mV, and lens conductance and 42K efflux rate stabilized at values close to the control values. These findings suggested that extended treatment with IAA increased the ratio of lens sodium to potassium permeability without increasing the overall leakiness of the lens.

AB - Sodium iodoacetate (IAA) at 10-3m was shown to cause a biphasic depolarization of the rabbit lens. The first portion of the depolarization was attributed to inhibition of the electrogenic sodium pump following depression of glycolysis. The larger second phase of lens depolarization, a transient increase both of lens conductance and 42K efflux rate, all indicate that IAA influences lens membrane permeability characteristics. After 100 min exposure to IAA, the lens potential stabilized at -39 mV, and lens conductance and 42K efflux rate stabilized at values close to the control values. These findings suggested that extended treatment with IAA increased the ratio of lens sodium to potassium permeability without increasing the overall leakiness of the lens.

KW - calcium

KW - electrolyte balance

KW - membrane permeability

KW - rabbit lens

KW - sodium iodoacetate

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Lens permeability changes associated with metabolic inhibition by iodoacetate

Abstract

Keywords

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