Leisure-time sedentary behaviors are differentially associated with all-cause dementia regardless of engagement in physical activity

David A. Raichlen, Yann C. Klimentidis, M. Katherine Sayre, Pradyumna K. Bharadwaj, Mark H.C. Lai, Rand R. Wilcox, Gene E. Alexander

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Sedentary behavior (SB) is associated with cardiometabolic disease and mortality, but its association with dementia is currently unclear. This study investigates whether SB is associated with incident dementia regardless of engagement in physical activity (PA). A total of 146,651 participants from the UK Biobank who were 60 years or older and did not have a diagnosis of dementia (mean [SD] age: 64.59 [2.84] years) were included. Self-reported leisure-time SBs were divided into two domains: time spent watching television (TV) or time spent using a computer. A total of 3,507 individuals were diagnosed with all-cause dementia over a mean follow-up of 11.87 (±1.17) years. In models adjusted for a wide range of covariates, including time spent in PA, time spent watching TV was associated with increased risk of incident dementia (HR [95% CI] = 1.24 [1.15 to 1.32]) and time spent using a computer was associated with decreased risk of incident dementia (HR [95% CI] = 0.85 [0.81 to 0.90]). In joint associations with PA, TV time and computer time remained significantly associated with dementia risk at all PA levels. Reducing time spent in cognitively passive SB (i.e., TV time) and increasing time spent in cognitively active SB (i.e., computer time) may be effective behavioral modification targets for reducing risk of dementia regardless of engagement in PA.

Original languageEnglish (US)
Article numbere2206931119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number35
DOIs
StatePublished - Aug 30 2022

Keywords

  • Alzheimer’s disease
  • brain health
  • exercise
  • sitting
  • television

ASJC Scopus subject areas

  • General

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