Learning- and cerebellum-dependent neuronal activity in the lateral pontine nucleus

Shaowen Bao, Lu Chen, Richard F. Thompson

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The effects of inactivation of cerebellar deep nuclei and the lateral pontine nucleus on classical eyeblink conditioning with tone or lateral reticular nucleus (LRN) stimulation as conditioned stimuli (CSs) were examined. Inactivation of cerebellar deep nuclei abolished eyeblink conditioned responses (CRs) when the CS was either a tone or LRN stimulation. Inactivation of the lateral pontine nucleus prevented only the acquisition and retention of tone-evoked eyeblink CRs. Multiple-unit recording demonstrated that when LRN stimulation was used as the CS, inactivation of the interpositus nucleus abolished learning-related neuronal activity in the lateral pontine nucleus, whereas inactivation of pontine nucleus had little effect on similar activity in the interpositus nucleus. Thus, the learning- induced neuronal activity in the lateral pontine nucleus was most likely driven by the cerebellar interpositus nucleus.

Original languageEnglish (US)
Pages (from-to)254-261
Number of pages8
JournalBehavioral Neuroscience
Volume114
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Behavioral Neuroscience

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