LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice

Daniel Muller; Beverly H. Koller; J. Lindsay Whitton; Katherine E. LaPan; Kristen K. Brigman; Jeffrey A. Frelinger

doi:10.1126/science.1347959

LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice

Daniel Muller, Beverly H. Koller, J. Lindsay Whitton, Katherine E. LaPan, Kristen K. Brigman, Jeffrey A. Frelinger

Immunobiology

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169 Scopus citations

Abstract

Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8⁺ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). β₂-Microglobulin-deficient mice (ß ₂M^-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8⁺ T cells. When β₂M^-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4 ⁺ CTLs that were class II-restricted. In these mice, CD4⁺ CTLs may compensate for the lack of CD8⁺ CTLs.

Original language	English (US)
Pages (from-to)	1576-1578
Number of pages	3
Journal	Science
Volume	255
Issue number	5051
DOIs	https://doi.org/10.1126/science.1347959
State	Published - 1992

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@article{60557495d06b4b8db2856ffa4e82c92c,

title = "LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice",

abstract = "Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). β2-Microglobulin-deficient mice ({\ss} 2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When β2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4 + CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.",

author = "Daniel Muller and Koller, {Beverly H.} and Whitton, {J. Lindsay} and LaPan, {Katherine E.} and Brigman, {Kristen K.} and Frelinger, {Jeffrey A.}",

year = "1992",

doi = "10.1126/science.1347959",

language = "English (US)",

volume = "255",

pages = "1576--1578",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5051",

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TY - JOUR

T1 - LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice

AU - Muller, Daniel

AU - Koller, Beverly H.

AU - Whitton, J. Lindsay

AU - LaPan, Katherine E.

AU - Brigman, Kristen K.

AU - Frelinger, Jeffrey A.

PY - 1992

Y1 - 1992

N2 - Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). β2-Microglobulin-deficient mice (ß 2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When β2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4 + CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.

AB - Intracranial infection of normal mice with lymphocytic choriomeningitis virus (LCMV) causes meningitis and death mediated by CD8+ major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes (CTLs). β2-Microglobulin-deficient mice (ß 2M-/-) do not express functional MHC class I proteins and do not produce significant numbers of CD8+ T cells. When β2M-/- mice were infected with LCMV, many died from LCMV disease and produced a specific response to LCMV mediated by CD4 + CTLs that were class II-restricted. In these mice, CD4+ CTLs may compensate for the lack of CD8+ CTLs.

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LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice

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