TY - JOUR
T1 - Lateral mobility of negative charge sites at the surface of sheep erythrocytes
AU - Marikovsky, Yehuda
AU - Weinstein, Ronald S.
N1 - Funding Information:
We gratefully acknowledge the technical assistance of MS Elaine Sundin, Mrs Benita Ramos, MS Carol Sanes Miller and Mr William Leonard, the photographic work of MS Denise Wiler and the editorial assistance of Mrs Sandra Velasco. One of the authors (Y. M.) greatly appreciates the warm hospitality extended to him bv the Department of Patholoav at Rush Medical College and Rush-Presbyter&-St Luke’s Medical Center, during his sabbatical visit. This work was supported by funds from the Otho Sprague Memorial Institute and from NIH Grant HL-24293.
PY - 1981/11
Y1 - 1981/11
N2 - Neuraminidase-sensitive negative charge sites on sheep red blood cells (SRBCs) are uniformly distributed over the cell surface, as in other species. Unlike most other species in which charge sites are immobile, however, in intact RBCs interaction of SRBCs with cationized ferritin (CF) induces clustering (i.e. patching) of CF-binding sites. This clustering is both time- and temperature-dependent. The clustering of negative charge sites results in the formation of domains up to 1 000 Å across which are totally free of CF binding sites. The unusually high degree of lateral mobility of ionogenic groups at the SRBC surface may contribute to the species specificity of E rosetting.
AB - Neuraminidase-sensitive negative charge sites on sheep red blood cells (SRBCs) are uniformly distributed over the cell surface, as in other species. Unlike most other species in which charge sites are immobile, however, in intact RBCs interaction of SRBCs with cationized ferritin (CF) induces clustering (i.e. patching) of CF-binding sites. This clustering is both time- and temperature-dependent. The clustering of negative charge sites results in the formation of domains up to 1 000 Å across which are totally free of CF binding sites. The unusually high degree of lateral mobility of ionogenic groups at the SRBC surface may contribute to the species specificity of E rosetting.
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U2 - 10.1016/0014-4827(81)90048-3
DO - 10.1016/0014-4827(81)90048-3
M3 - Article
C2 - 7297609
AN - SCOPUS:0019799417
SN - 0014-4827
VL - 136
SP - 169
EP - 175
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 1
ER -