Lateral mobility of negative charge sites at the surface of sheep erythrocytes

Yehuda Marikovsky, Ronald S. Weinstein

Research output: Contribution to journalArticlepeer-review


Neuraminidase-sensitive negative charge sites on sheep red blood cells (SRBCs) are uniformly distributed over the cell surface, as in other species. Unlike most other species in which charge sites are immobile, however, in intact RBCs interaction of SRBCs with cationized ferritin (CF) induces clustering (i.e. patching) of CF-binding sites. This clustering is both time- and temperature-dependent. The clustering of negative charge sites results in the formation of domains up to 1 000 Å across which are totally free of CF binding sites. The unusually high degree of lateral mobility of ionogenic groups at the SRBC surface may contribute to the species specificity of E rosetting.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalExperimental Cell Research
Issue number1
StatePublished - Nov 1981

ASJC Scopus subject areas

  • Cell Biology


Dive into the research topics of 'Lateral mobility of negative charge sites at the surface of sheep erythrocytes'. Together they form a unique fingerprint.

Cite this