Latent cytomegalovirus infection and innate immune function following a 75 km cycling time trial

Emily C.P. Lavoy, David C. Nieman, Dru A. Henson, R. Andrew Shanely, Amy M. Knab, Lynn Cialdella-Kam, Richard J. Simpson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose: This study compared the acute immune response, inflammation, and lipid peroxidation to a 75 km cycling time trial in male athletes testing positive or negative for latent cytomegalovirus (CMV) infection. Design: Trained cyclists (N = 20) were tested for CMV serostatus, and cycled 75 km on a mountainous course using indoor trainers with continuous workload monitoring. Pre-, post-, and 1 h post-exercise blood samples were analyzed for total blood leukocyte counts, blood granulocyte (GR) and monocyte (MO) phagocytosis (PHAG) and oxidative burst activity (OBA), four plasma cytokines, and plasma F 2-isoprostanes. Results: Forty percent of the subjects tested positive for CMV. No differences in subject characteristics were found between CMVpos and CMVneg groups. Mean power (57.3 ± 1.6, 59.4 ± 1.8 % maximal Watts, p = 0.803), heart rate (87.0 ± 1.0, 86.5 ± 1.3 % maximal heart rate, p = 0.376), and total time (2.56 ± 0.08, 2.60 ± 0.08 h, p = 0.744) to complete the 75 km cycling time trial did not differ between CMVpos and CMVneg groups. Whereas exercise induced significant changes in total blood leukocyte counts, GR and MO-PHAG, four plasma cytokines, and plasma F2- isoprostanes (p < 0.05, ω2 > 0.03), these exercise-induced changes did not differ between CMVpos and CMV neg groups (p > 0.05, ω2 < 0.01). Conclusions: CMV serostatus does not appear to influence these innate immune responses or markers of inflammation and lipid peroxidation in response to a single bout of heavy exertion.

Original languageEnglish (US)
Pages (from-to)2629-2635
Number of pages7
JournalEuropean Journal of Applied Physiology
Volume113
Issue number10
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • CMV serostatus
  • Cycling
  • Cytokines
  • Innate immune function
  • Oxidative stress

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

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