Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy

Céline Bourgier, Jérôme Lacombe, JérÔme Solassol, Alain Mange, André Pèlegrin, Mahmut Ozsahin, David Azria

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Radiation therapy undeniably enhances local control and thus improves overall survival in cancer patients. However, some long-term cancer survivors (less than 10%) develop severe late radio-induced toxicities altering their quality of life. Therefore, there is a need to identify patients who are sensitive to those toxicities and who could benefit from adapted care. In this review, we address all available techniques aiming to detect patients' hyper-radiosensitivity and present the scientific rationales these techniques are based on.

Original languageEnglish (US)
Pages (from-to)312-319
Number of pages8
JournalCritical Reviews in Oncology/Hematology
Volume93
Issue number3
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

Keywords

  • Predictive markers
  • Radiotherapy outcome

ASJC Scopus subject areas

  • Hematology
  • Oncology

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