TY - JOUR
T1 - Large-vessel distensibility measurement with electrocardiographically gated multidetector CT
T2 - Phantom study and initial experience
AU - Zhang, Jie
AU - Fletcher, Joel G.
AU - Vrtiska, Terri J.
AU - Manduca, Armando
AU - Thompson, Jess L.
AU - Raghavan, Madhavan L.
AU - Wentz, Robert J.
AU - McCollough, Cynthia H.
PY - 2007/10
Y1 - 2007/10
N2 - The purpose of this study was to prospectively examine vessel distensibility measurements by using electrocardiographically gated multidetector computed tomography (CT) in a phantom compared with measurements by using a digital camera and to examine feasibility in humans. Large-vessel phantoms were constructed, using a pulsatile flow pump, and absolute diameter and percentage diameter changes during pulsation were measured. After institutional review board approval and patient consent were obtained, the abdominal aorta of four patients was scanned with an electrocardiographically gated CT protocol. The mean difference in percentage diameter change between CT and optical measurements for the phantom ranged from -0.47% to 0.14%. The range of area changes in five locations along the abdominal aorta in four patients was 2.97%-37.16%. Findings of this study indicate that electrocardiographically gated CT angiography data reconstructed across cardiac phases permit measurements of large-vessel distensibility in a phantom model and that vessel distensibility measurement in humans may be possible.
AB - The purpose of this study was to prospectively examine vessel distensibility measurements by using electrocardiographically gated multidetector computed tomography (CT) in a phantom compared with measurements by using a digital camera and to examine feasibility in humans. Large-vessel phantoms were constructed, using a pulsatile flow pump, and absolute diameter and percentage diameter changes during pulsation were measured. After institutional review board approval and patient consent were obtained, the abdominal aorta of four patients was scanned with an electrocardiographically gated CT protocol. The mean difference in percentage diameter change between CT and optical measurements for the phantom ranged from -0.47% to 0.14%. The range of area changes in five locations along the abdominal aorta in four patients was 2.97%-37.16%. Findings of this study indicate that electrocardiographically gated CT angiography data reconstructed across cardiac phases permit measurements of large-vessel distensibility in a phantom model and that vessel distensibility measurement in humans may be possible.
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U2 - 10.1148/radiol.2451060530
DO - 10.1148/radiol.2451060530
M3 - Article
C2 - 17885194
AN - SCOPUS:34548776354
SN - 0033-8419
VL - 245
SP - 258
EP - 266
JO - Radiology
JF - Radiology
IS - 1
ER -