Lack of effect of diazepam on methadone metabolism in methadone-maintained addicts

Susan M. Pond; Theodore G. Tong; Neal L. Benowitz; Peyton Jacob; Jean Rigod

doi:10.1038/clpt.1982.22

Lack of effect of diazepam on methadone metabolism in methadone-maintained addicts

Susan M. Pond, Theodore G. Tong, Neal L. Benowitz, Peyton Jacob, Jean Rigod

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Four methadone-maintained subjects were given diazepam (0.3 mg/kg) for 9 days. During the dual drug period, the effects and kinetics of methadone and of its major pyrrolidine metabolite were not altered. These findings indicate that, unlike its effects in rodents, diazepam does not inhibit the metabolism of methadone in man.

Original language	English (US)
Pages (from-to)	139-143
Number of pages	5
Journal	Clinical Pharmacology and Therapeutics
Volume	31
Issue number	2
DOIs	https://doi.org/10.1038/clpt.1982.22
State	Published - Feb 1982
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1038/clpt.1982.22

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abstract = "Four methadone-maintained subjects were given diazepam (0.3 mg/kg) for 9 days. During the dual drug period, the effects and kinetics of methadone and of its major pyrrolidine metabolite were not altered. These findings indicate that, unlike its effects in rodents, diazepam does not inhibit the metabolism of methadone in man.",

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AB - Four methadone-maintained subjects were given diazepam (0.3 mg/kg) for 9 days. During the dual drug period, the effects and kinetics of methadone and of its major pyrrolidine metabolite were not altered. These findings indicate that, unlike its effects in rodents, diazepam does not inhibit the metabolism of methadone in man.

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Lack of effect of diazepam on methadone metabolism in methadone-maintained addicts

Abstract

ASJC Scopus subject areas

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