Label-Free biological and chemical sensing using whispering gallery mode optical resonators: Past, present, and future

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Sensitive and rapid label-free biological and chemical sensors are needed for a wide variety of applications including early disease diagnosis and prognosis, the monitoring of food and water quality, as well as the detection of bacteria and viruses for public health concerns and chemical threat sensing. Whispering gallery mode optical resonator based sensing is a rapidly developing field due to the high sensitivity and speed of these devices as well as their label-free nature. Here, we describe the history of whispering gallery mode optical resonator sensors, the principles behind detection, the latest developments in the fields of biological and chemical sensing, current challenges toward widespread adoption of these devices, and an outlook for the future. In addition, we evaluate the performance capabilities of these sensors across three key parameters: sensitivity, selectivity, and speed.

Original languageEnglish (US)
Article number540
JournalSensors (Switzerland)
Volume17
Issue number3
DOIs
StatePublished - Mar 8 2017
Externally publishedYes

Keywords

  • Biosensing
  • Chemical sensing
  • Label-free
  • Microcavity
  • Optical resonator
  • Single molecule
  • Whispering gallery mode

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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