L-type voltage-sensitive calcium channel activation stimulates gene expression by a serum response factor-dependent pathway

Ravi P. Misra, Azad Bonni, Cindy K. Miranti, Victor M. Rivera, Morgan Sheng, Michael E. Greenberg

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149 Scopus citations


A mechanism by which calcium-induced signals are transduced to the nucleus to activate transcription of the c-fos proto-oncogene has been characterized. The serum response element (SRE), a region of the c-fos gene which controls growth factor-induced transcription, is now shown to mediate c-fos transcription in response to activation of L-type voltage-sensitive calcium channels. Calcium-dependent transcriptional activation through the SRE is mediated by the serum response factor (SRF). Membrane depolarization induces phosphorylation of SRF at Ser-103, an event shown to enhance the ability of SRF to bind the SRE. Ca2+-induced SRF phosphorylation occurs via a pathway that may involve Ca2+/calmodulin-dependent kinases.

Original languageEnglish (US)
Pages (from-to)25483-25493
Number of pages11
JournalJournal of Biological Chemistry
Issue number41
StatePublished - Oct 14 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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