L-Glutaminase: Suppression of lymphocyte blastogenic responses in vitro

Evan M. Hersh

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Continuous exposure to 0.1 international unit or more of Escherichia coli L-glutaminase inhibited responses of human lymphocytes to phytohemagglutinin, streptolysin O, and allogeneic leukocytes. Inhibition was completely reversed by removing the enzyme from the culture or adding L-glutamine but not L-asparagine. Cytoxicity did not occur. L-Glutaminase should be immunosuppressive in vivo.

Original languageEnglish (US)
Pages (from-to)736-738
Number of pages3
Issue number3984
StatePublished - 1971
Externally publishedYes

ASJC Scopus subject areas

  • General


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